TY - JOUR
T1 - Polymeric carriers
T2 - Role of geometry in drug delivery
AU - Simone, Eric A.
AU - Dziubla, Thomas D.
AU - Muzykantov, Vladimir R.
PY - 2008/12
Y1 - 2008/12
N2 - The unique properties of synthetic nanostructures promise a diverse set of applications as carriers for drug delivery, which are advantageous in terms of biocompatibility, pharmacokinetics, targeting and controlled drug release. Historically, more traditional drug delivery systems have focused on spherical carriers. However, there is a growing interest in pursuing non-spherical carriers, such as elongated or filamentous morphologies, now available due to novel formulation strategies. Unique physiochemical properties of these supramolecular structures offer distinct advantages as drug delivery systems. In particular, results of recent studies in cell cultures and lab animals indicate that rational design of carriers of a given geometry (size and shape) offers an unprecedented control of their longevity in circulation and targeting to selected cellular and subcellular locations. This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing.
AB - The unique properties of synthetic nanostructures promise a diverse set of applications as carriers for drug delivery, which are advantageous in terms of biocompatibility, pharmacokinetics, targeting and controlled drug release. Historically, more traditional drug delivery systems have focused on spherical carriers. However, there is a growing interest in pursuing non-spherical carriers, such as elongated or filamentous morphologies, now available due to novel formulation strategies. Unique physiochemical properties of these supramolecular structures offer distinct advantages as drug delivery systems. In particular, results of recent studies in cell cultures and lab animals indicate that rational design of carriers of a given geometry (size and shape) offers an unprecedented control of their longevity in circulation and targeting to selected cellular and subcellular locations. This article reviews drug delivery aspects of non-spherical drug delivery systems, including material selection and formulation, drug loading and release, biocompatibility, circulation behavior, targeting and subcellular addressing.
KW - Formulation
KW - Geometry
KW - Micelle
KW - Nano
KW - Polymer
UR - http://www.scopus.com/inward/record.url?scp=58149186706&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=58149186706&partnerID=8YFLogxK
U2 - 10.1517/17425240802567846
DO - 10.1517/17425240802567846
M3 - Review article
C2 - 19040392
AN - SCOPUS:58149186706
SN - 1742-5247
VL - 5
SP - 1283
EP - 1300
JO - Expert Opinion on Drug Delivery
JF - Expert Opinion on Drug Delivery
IS - 12
ER -