Polymorphism and conservation of the genes encoding Qa1 molecules

Evan Hermel; Andrew J. Hart; Irfan Gunduz; Hector Acton; Christina Kim; Mark Wurth; Samina Uddin; Caryn Smith; Kirsten Fischer Lindahl; Carla J. Aldrich

doi:10.1007/s00251-004-0722-x

Polymorphism and conservation of the genes encoding Qa1 molecules

Evan Hermel, Andrew J. Hart, Irfan Gunduz, Hector Acton, Christina Kim, Mark Wurth, Samina Uddin, Caryn Smith, Kirsten Fischer Lindahl, Carla J. Aldrich

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1^a-like and Qa1^b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

Original language	English
Pages (from-to)	639-649
Number of pages	11
Journal	Immunogenetics
Volume	56
Issue number	9
DOIs	https://doi.org/10.1007/s00251-004-0722-x
State	Published - Dec 2004

Bibliographical note

Funding Information:
Acknowledgements We thank Carolyn (Lucy) Shuck and Amy Samm for expert technical assistance and Diana Fuqua, Margaretan Stolfo and Anne Eubanks for excellence in animal breeding and care. Cell irradiation was kindly provided by the Evansville Cancer Center. This work was supported in part by grant JFRA-645 from the American Cancer Society, and Indiana University Diabetes and Research Center NIH grant P60 DK20542 (CJA) and NIH grant AI37818 (KFL).

Keywords

Cytotoxic T lymphocyte
H2-Qa1
H2-T23
MHC class Ib
Mus spretus
Wild mice

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/s00251-004-0722-x

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title = "Polymorphism and conservation of the genes encoding Qa1 molecules",

abstract = "To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.",

keywords = "Cytotoxic T lymphocyte, H2-Qa1, H2-T23, MHC class Ib, Mus spretus, Wild mice",

author = "Evan Hermel and Hart, {Andrew J.} and Irfan Gunduz and Hector Acton and Christina Kim and Mark Wurth and Samina Uddin and Caryn Smith and Lindahl, {Kirsten Fischer} and Aldrich, {Carla J.}",

note = "Funding Information: Acknowledgements We thank Carolyn (Lucy) Shuck and Amy Samm for expert technical assistance and Diana Fuqua, Margaretan Stolfo and Anne Eubanks for excellence in animal breeding and care. Cell irradiation was kindly provided by the Evansville Cancer Center. This work was supported in part by grant JFRA-645 from the American Cancer Society, and Indiana University Diabetes and Research Center NIH grant P60 DK20542 (CJA) and NIH grant AI37818 (KFL).",

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doi = "10.1007/s00251-004-0722-x",

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AU - Hart, Andrew J.

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AU - Acton, Hector

AU - Kim, Christina

AU - Wurth, Mark

AU - Uddin, Samina

AU - Smith, Caryn

AU - Lindahl, Kirsten Fischer

AU - Aldrich, Carla J.

N1 - Funding Information: Acknowledgements We thank Carolyn (Lucy) Shuck and Amy Samm for expert technical assistance and Diana Fuqua, Margaretan Stolfo and Anne Eubanks for excellence in animal breeding and care. Cell irradiation was kindly provided by the Evansville Cancer Center. This work was supported in part by grant JFRA-645 from the American Cancer Society, and Indiana University Diabetes and Research Center NIH grant P60 DK20542 (CJA) and NIH grant AI37818 (KFL).

PY - 2004/12

Y1 - 2004/12

N2 - To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

AB - To evaluate the polymorphism and conservation of the major histocompatibility complex class Ib molecule Qa1 in wild mouse populations, we determined the nucleotide sequence of exons 1-3 of Qa1 of eight mouse haplotypes derived from wild mice, including Mus musculus domesticus, M. m. castaneus, M. m. bactrianus, and M. spretus, as well as two t haplotypes. Our data identify eight new alleles of Qa1. Taken together with previously published data on Qa1 among the common laboratory inbred strains, and in agreement with cytotoxic T-lymphocyte, serological, and biochemical data, these results further confirm the existence of two families of Qa1 molecules, Qa1a-like and Qa1b-like, and illuminate the extreme conservation of the peptide-binding region of these molecules, even across species.

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KW - MHC class Ib

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Polymorphism and conservation of the genes encoding Qa1 molecules

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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