Polymorphisms in oxidative stress pathway genes and prostate cancer risk

Zhenzhen Zhang; Duo Jiang; Chi Wang; Mark Garzotto; Ryan Kopp; Beth Wilmot; Philippe Thuillier; Andy Dang; Amy Palma; Paige E. Farris; Jackilen Shannon

doi:10.1007/s10552-019-01242-7

Polymorphisms in oxidative stress pathway genes and prostate cancer risk

Zhenzhen Zhang, Duo Jiang, Chi Wang, Mark Garzotto, Ryan Kopp, Beth Wilmot, Philippe Thuillier, Andy Dang, Amy Palma, Paige E. Farris, Jackilen Shannon

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

Purpose: Age-related factors including oxidative stress play an important role in prostate carcinogenesis. We hypothesize that germline single-nucleotide polymorphisms (SNPs) in oxidative stress pathway are associated with prostate cancer (PCa) risk. In this study, we aim to examine which of these SNPs is associated with PCa. Methods: Participants included in this analyses came from the “Genetic Susceptibility, Environment and Prostate Cancer Risk Study” conducted at the Veterans Affairs Portland Health Care System. After applying exclusion criteria, 231 PCa cases and 382 prostate biopsy-negative controls who had genotyping data on twenty-two single-nucleotide polymorphisms (SNPs) in six genes (MAPK14, NRF2, CAT, GPX1, GSTP1, SOD2, and XDH) associated with oxidative stress pathway were included in the analyses. The genotyping of SNPs was conducted by the Illumina BeadXpress VeraCode platform. We investigated these SNPs in relation to overall and aggressive PCa risk using logistic regression models controlling for relevant covariates. Results: One SNP in the MAPK14 (rs851023) was significantly associated with incident PCa risk. Compared to men carrying two copies of allele A, the presence of one or two copies of the G allele was associated with decreased risk of PCa [OR (95% CI) 0.19 (0.06–0.51)]. There was no statistically significant association between other SNPs in the NRF2, CAT, GPX1, GSTP1, SOD2, and XDH genes and PCa risk. Conclusions: The MAPK14 gene SNP rs851023 was associated with PCa and aggressive PCa risk after multiple comparison adjustment. Further studies in other populations or functional studies are needed to validate the finding.

Original language	English
Pages (from-to)	1365-1375
Number of pages	11
Journal	Cancer Causes and Control
Volume	30
Issue number	12
DOIs	https://doi.org/10.1007/s10552-019-01242-7
State	Published - Dec 1 2019

Bibliographical note

Funding Information:
We greatly appreciate all the veterans and their family members who contributed their time and effort to join the Genetic Susceptibility, Environment and Prostate Cancer Risk (GSEP) study. Gratitude is expressed to our large list of collaborators and providers of tools to make this project successful; use of Case Western University’s Genetic Risk Easy Assessment Tool (GREAT) was provided by Dr. Louise Acheson; Oregon Clinical and Translational Research Institute’s (OCTRI) Biomedical Informatics Program was instrumental in tying all of our electronic questionnaires together into one HIPAA-compliant portal; VAPHCS phlebotomy staff helped us collect research specimens and allowing laboratory space for saliva collection; OCTRI’s Clinical and Translational Research Center (CTRC) Core Laboratory processed, analyzed, and stored subjects’ biological specimens; genotyping was conducted by iGenix in Seattle, Washington. Dr. Shannon’s current and previous research coordinators spent large amounts of time with our numerous in-person and over-the-phone participants in support of this study, assuring quality data collection as well as close, personal attention to our nation’s veterans and their family members choosing to join this study. We are also grateful to VAPHCS Urology Nurses and Operative Care staff for supporting coordinators’ recruitment of research participants.

Funding Information:
Research reported in this publication was supported by the Veterans Affairs’ Biomedical Laboratory Research and Development Merit Review Award, VA Portland Health Care System (VAPHCS), and by the National Center for Advancing Translational Sciences of the National Institutes of Health under award number UL1TR000128. Clinical Trial Registration’s clinicaltrials.gov identifier: NCT01013129. This work was directly supported by the Veterans Affairs’ Biomedical Laboratory Research and Development Merit Review Award, and Oregon Health & Science University/Oregon State University Cancer Prevention and Control Initiative (2017-Horizon-Knight-11). Acknowledgments

Publisher Copyright:
© 2019, Springer Nature Switzerland AG.

Keywords

Oxidative stress genes
Prostate cancer
SNP

ASJC Scopus subject areas

Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s10552-019-01242-7

Cite this

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title = "Polymorphisms in oxidative stress pathway genes and prostate cancer risk",

abstract = "Purpose: Age-related factors including oxidative stress play an important role in prostate carcinogenesis. We hypothesize that germline single-nucleotide polymorphisms (SNPs) in oxidative stress pathway are associated with prostate cancer (PCa) risk. In this study, we aim to examine which of these SNPs is associated with PCa. Methods: Participants included in this analyses came from the “Genetic Susceptibility, Environment and Prostate Cancer Risk Study” conducted at the Veterans Affairs Portland Health Care System. After applying exclusion criteria, 231 PCa cases and 382 prostate biopsy-negative controls who had genotyping data on twenty-two single-nucleotide polymorphisms (SNPs) in six genes (MAPK14, NRF2, CAT, GPX1, GSTP1, SOD2, and XDH) associated with oxidative stress pathway were included in the analyses. The genotyping of SNPs was conducted by the Illumina BeadXpress VeraCode platform. We investigated these SNPs in relation to overall and aggressive PCa risk using logistic regression models controlling for relevant covariates. Results: One SNP in the MAPK14 (rs851023) was significantly associated with incident PCa risk. Compared to men carrying two copies of allele A, the presence of one or two copies of the G allele was associated with decreased risk of PCa [OR (95% CI) 0.19 (0.06–0.51)]. There was no statistically significant association between other SNPs in the NRF2, CAT, GPX1, GSTP1, SOD2, and XDH genes and PCa risk. Conclusions: The MAPK14 gene SNP rs851023 was associated with PCa and aggressive PCa risk after multiple comparison adjustment. Further studies in other populations or functional studies are needed to validate the finding.",

keywords = "Oxidative stress genes, Prostate cancer, SNP",

author = "Zhenzhen Zhang and Duo Jiang and Chi Wang and Mark Garzotto and Ryan Kopp and Beth Wilmot and Philippe Thuillier and Andy Dang and Amy Palma and Farris, {Paige E.} and Jackilen Shannon",

note = "Funding Information: We greatly appreciate all the veterans and their family members who contributed their time and effort to join the Genetic Susceptibility, Environment and Prostate Cancer Risk (GSEP) study. Gratitude is expressed to our large list of collaborators and providers of tools to make this project successful; use of Case Western University{\textquoteright}s Genetic Risk Easy Assessment Tool (GREAT) was provided by Dr. Louise Acheson; Oregon Clinical and Translational Research Institute{\textquoteright}s (OCTRI) Biomedical Informatics Program was instrumental in tying all of our electronic questionnaires together into one HIPAA-compliant portal; VAPHCS phlebotomy staff helped us collect research specimens and allowing laboratory space for saliva collection; OCTRI{\textquoteright}s Clinical and Translational Research Center (CTRC) Core Laboratory processed, analyzed, and stored subjects{\textquoteright} biological specimens; genotyping was conducted by iGenix in Seattle, Washington. Dr. Shannon{\textquoteright}s current and previous research coordinators spent large amounts of time with our numerous in-person and over-the-phone participants in support of this study, assuring quality data collection as well as close, personal attention to our nation{\textquoteright}s veterans and their family members choosing to join this study. We are also grateful to VAPHCS Urology Nurses and Operative Care staff for supporting coordinators{\textquoteright} recruitment of research participants. Funding Information: Research reported in this publication was supported by the Veterans Affairs{\textquoteright} Biomedical Laboratory Research and Development Merit Review Award, VA Portland Health Care System (VAPHCS), and by the National Center for Advancing Translational Sciences of the National Institutes of Health under award number UL1TR000128. Clinical Trial Registration{\textquoteright}s clinicaltrials.gov identifier: NCT01013129. This work was directly supported by the Veterans Affairs{\textquoteright} Biomedical Laboratory Research and Development Merit Review Award, and Oregon Health & Science University/Oregon State University Cancer Prevention and Control Initiative (2017-Horizon-Knight-11). Acknowledgments Publisher Copyright: {\textcopyright} 2019, Springer Nature Switzerland AG.",

year = "2019",

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doi = "10.1007/s10552-019-01242-7",

language = "English",

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T1 - Polymorphisms in oxidative stress pathway genes and prostate cancer risk

AU - Zhang, Zhenzhen

AU - Jiang, Duo

AU - Wang, Chi

AU - Garzotto, Mark

AU - Kopp, Ryan

AU - Wilmot, Beth

AU - Thuillier, Philippe

AU - Dang, Andy

AU - Palma, Amy

AU - Farris, Paige E.

AU - Shannon, Jackilen

N1 - Funding Information: We greatly appreciate all the veterans and their family members who contributed their time and effort to join the Genetic Susceptibility, Environment and Prostate Cancer Risk (GSEP) study. Gratitude is expressed to our large list of collaborators and providers of tools to make this project successful; use of Case Western University’s Genetic Risk Easy Assessment Tool (GREAT) was provided by Dr. Louise Acheson; Oregon Clinical and Translational Research Institute’s (OCTRI) Biomedical Informatics Program was instrumental in tying all of our electronic questionnaires together into one HIPAA-compliant portal; VAPHCS phlebotomy staff helped us collect research specimens and allowing laboratory space for saliva collection; OCTRI’s Clinical and Translational Research Center (CTRC) Core Laboratory processed, analyzed, and stored subjects’ biological specimens; genotyping was conducted by iGenix in Seattle, Washington. Dr. Shannon’s current and previous research coordinators spent large amounts of time with our numerous in-person and over-the-phone participants in support of this study, assuring quality data collection as well as close, personal attention to our nation’s veterans and their family members choosing to join this study. We are also grateful to VAPHCS Urology Nurses and Operative Care staff for supporting coordinators’ recruitment of research participants. Funding Information: Research reported in this publication was supported by the Veterans Affairs’ Biomedical Laboratory Research and Development Merit Review Award, VA Portland Health Care System (VAPHCS), and by the National Center for Advancing Translational Sciences of the National Institutes of Health under award number UL1TR000128. Clinical Trial Registration’s clinicaltrials.gov identifier: NCT01013129. This work was directly supported by the Veterans Affairs’ Biomedical Laboratory Research and Development Merit Review Award, and Oregon Health & Science University/Oregon State University Cancer Prevention and Control Initiative (2017-Horizon-Knight-11). Acknowledgments Publisher Copyright: © 2019, Springer Nature Switzerland AG.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - Purpose: Age-related factors including oxidative stress play an important role in prostate carcinogenesis. We hypothesize that germline single-nucleotide polymorphisms (SNPs) in oxidative stress pathway are associated with prostate cancer (PCa) risk. In this study, we aim to examine which of these SNPs is associated with PCa. Methods: Participants included in this analyses came from the “Genetic Susceptibility, Environment and Prostate Cancer Risk Study” conducted at the Veterans Affairs Portland Health Care System. After applying exclusion criteria, 231 PCa cases and 382 prostate biopsy-negative controls who had genotyping data on twenty-two single-nucleotide polymorphisms (SNPs) in six genes (MAPK14, NRF2, CAT, GPX1, GSTP1, SOD2, and XDH) associated with oxidative stress pathway were included in the analyses. The genotyping of SNPs was conducted by the Illumina BeadXpress VeraCode platform. We investigated these SNPs in relation to overall and aggressive PCa risk using logistic regression models controlling for relevant covariates. Results: One SNP in the MAPK14 (rs851023) was significantly associated with incident PCa risk. Compared to men carrying two copies of allele A, the presence of one or two copies of the G allele was associated with decreased risk of PCa [OR (95% CI) 0.19 (0.06–0.51)]. There was no statistically significant association between other SNPs in the NRF2, CAT, GPX1, GSTP1, SOD2, and XDH genes and PCa risk. Conclusions: The MAPK14 gene SNP rs851023 was associated with PCa and aggressive PCa risk after multiple comparison adjustment. Further studies in other populations or functional studies are needed to validate the finding.

AB - Purpose: Age-related factors including oxidative stress play an important role in prostate carcinogenesis. We hypothesize that germline single-nucleotide polymorphisms (SNPs) in oxidative stress pathway are associated with prostate cancer (PCa) risk. In this study, we aim to examine which of these SNPs is associated with PCa. Methods: Participants included in this analyses came from the “Genetic Susceptibility, Environment and Prostate Cancer Risk Study” conducted at the Veterans Affairs Portland Health Care System. After applying exclusion criteria, 231 PCa cases and 382 prostate biopsy-negative controls who had genotyping data on twenty-two single-nucleotide polymorphisms (SNPs) in six genes (MAPK14, NRF2, CAT, GPX1, GSTP1, SOD2, and XDH) associated with oxidative stress pathway were included in the analyses. The genotyping of SNPs was conducted by the Illumina BeadXpress VeraCode platform. We investigated these SNPs in relation to overall and aggressive PCa risk using logistic regression models controlling for relevant covariates. Results: One SNP in the MAPK14 (rs851023) was significantly associated with incident PCa risk. Compared to men carrying two copies of allele A, the presence of one or two copies of the G allele was associated with decreased risk of PCa [OR (95% CI) 0.19 (0.06–0.51)]. There was no statistically significant association between other SNPs in the NRF2, CAT, GPX1, GSTP1, SOD2, and XDH genes and PCa risk. Conclusions: The MAPK14 gene SNP rs851023 was associated with PCa and aggressive PCa risk after multiple comparison adjustment. Further studies in other populations or functional studies are needed to validate the finding.

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KW - Prostate cancer

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Polymorphisms in oxidative stress pathway genes and prostate cancer risk

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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Cite this