Polyphenol conjugated poly(beta-amino ester) polymers with hydrogen peroxide triggered degradation and active antioxidant release

Carolyn T. Jordan, J. Zach Hilt, Thomas D. Dziubla

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Oxidative stress has been implicated as a primary or secondary player to numerous diseases. A potential approach to control oxidative stress induced diseases is to deliver small antioxidant compounds to compromised sites at equivalent rates of reactive oxygen species (ROS) generation. This becomes a complicated task as antioxidant molecules typically have poor bioavailability and stability. Antioxidants synthesized into poly(beta-amino ester) (PBAE) crosslinked polymers have shown improved delivery by enhancing stability while allowing controlled release through hydrolysis. The tunable crosslinked networks show significant response to specific oxidizing environments, where free radicals can be present. Curcumin conjugated PBAE bulk films have proportional rates of accelerated degradation, thus faster release of curcumin, in a range of low concentrations of hydrogen peroxide (H2O2), where 2′2-azobis(2-amidinopropane) dihydrochloride has no substantial impact. This effect suggests the possibility to create a system that releases its therapeutic agent in direct relationship to the need through ROS signaling.

Original languageEnglish
Article number48647
JournalJournal of Applied Polymer Science
Issue number25
StatePublished - Jul 5 2020

Bibliographical note

Funding Information:
The project was supported by the National Institute of Dental and Craniofacial Institute (NIDCR, Grant Number R44DE023523) awarded to Bluegrass Advanced Materials, LLC (BAM). The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIDCR.

Publisher Copyright:
© 2019 Wiley Periodicals, Inc.


  • biodegradable
  • biomedical applications
  • drug delivery systems

ASJC Scopus subject areas

  • Chemistry (all)
  • Surfaces, Coatings and Films
  • Polymers and Plastics
  • Materials Chemistry


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