Polypyrrole nanospheres with magnetic and cell-targeting capabilities

Shy Chyi Wuang; Koon Gee Neoh; En Tang Kang; Daniel W. Pack; Deborah E. Leckband

doi:10.1002/marc.200600873

Polypyrrole nanospheres with magnetic and cell-targeting capabilities

Shy Chyi Wuang, Koon Gee Neoh, En Tang Kang, Daniel W. Pack, Deborah E. Leckband

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The preparation of polypyrrole/Fe₃O₄ nanospheres by a facile mini-emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well-dispersed nanospheres of 80-100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe₃O ₄ nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells.

Original language	English
Pages (from-to)	816-821
Number of pages	6
Journal	Macromolecular Rapid Communications
Volume	28
Issue number	7
DOIs	https://doi.org/10.1002/marc.200600873
State	Published - Apr 2 2007

Keywords

Cancer cell-targeting
Emulsion polymerization
Hyaluronic acid
Polypyrrole/FeO nanospheres
Surfactants

ASJC Scopus subject areas

Organic Chemistry
Polymers and Plastics
Materials Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/marc.200600873

Cite this

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title = "Polypyrrole nanospheres with magnetic and cell-targeting capabilities",

abstract = "The preparation of polypyrrole/Fe3O4 nanospheres by a facile mini-emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well-dispersed nanospheres of 80-100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe3O 4 nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells.",

keywords = "Cancer cell-targeting, Emulsion polymerization, Hyaluronic acid, Polypyrrole/FeO nanospheres, Surfactants",

author = "Wuang, {Shy Chyi} and Neoh, {Koon Gee} and Kang, {En Tang} and Pack, {Daniel W.} and Leckband, {Deborah E.}",

year = "2007",

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doi = "10.1002/marc.200600873",

language = "English",

volume = "28",

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T1 - Polypyrrole nanospheres with magnetic and cell-targeting capabilities

AU - Wuang, Shy Chyi

AU - Neoh, Koon Gee

AU - Kang, En Tang

AU - Pack, Daniel W.

AU - Leckband, Deborah E.

PY - 2007/4/2

Y1 - 2007/4/2

N2 - The preparation of polypyrrole/Fe3O4 nanospheres by a facile mini-emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well-dispersed nanospheres of 80-100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe3O 4 nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells.

AB - The preparation of polypyrrole/Fe3O4 nanospheres by a facile mini-emulsion polymerization method is investigated using poly(ethylene glycol), poly(ethylene oxide), poly(vinyl alcohol), and hyaluronic acid as surfactants. Hyaluronic acid is deemed the most suitable surfactant since it results in well-dispersed nanospheres of 80-100 nm, and offers the advantages of biocompatibility, cell adhesive property, and the availability of functional groups for attachment of other molecules. These polypyrrole/Fe3O 4 nanospheres are magnetic and can be further functionalized with a cancer antibody, herceptin. Our results show that this combination of hyaluronic acid and herceptin results in high specific uptake of the nanospheres by cancer cells.

KW - Cancer cell-targeting

KW - Emulsion polymerization

KW - Hyaluronic acid

KW - Polypyrrole/FeO nanospheres

KW - Surfactants

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DO - 10.1002/marc.200600873

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JO - Macromolecular Rapid Communications

JF - Macromolecular Rapid Communications

IS - 7

ER -

Polypyrrole nanospheres with magnetic and cell-targeting capabilities

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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