Polytocus focus: Uterine position effect is dependent upon horn size

Kristen A. McLaurin; Charles F. Mactutus

doi:10.1016/j.ijdevneu.2014.11.001

Polytocus focus: Uterine position effect is dependent upon horn size

Kristen A. McLaurin
, Charles F. Mactutus

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Understanding the variability caused by uterine position effects in polytocus species, such as rats, may enhance prenatal animal models for the study of drug and environmental agents. The primiparous litters of 42 intact female Sprague-Dawley rats were studied. Uterine position, fetal body weight, and fetal brain (wet) weight were recorded on gestation day (GD) 20 (GD 0. =. sperm positive). Uterine position effect for brain and body weight varied depending upon horn size. Furthermore, an inverse relationship between horn size (and, to a lesser extent, litter size) and fetal weight applied to both body and brain weight measures. There were no statistical differences in brain and body weights between the left and right uterine horns. The position of the uterine horn (left vs. right) and litter size did not influence the uterine position effect in the rat. Collectively, the present data suggest the presence of a significant uterine position effect. Prenatal differences based on uterine position provide an untapped opportunity to increase our understanding of developmental neurotoxicological and teratological studies that employ a polytocus species as an animal model.

Original language	English
Pages (from-to)	85-91
Number of pages	7
Journal	International Journal of Developmental Neuroscience
Volume	40
DOIs	https://doi.org/10.1016/j.ijdevneu.2014.11.001
State	Published - Feb 1 2015

Bibliographical note

Publisher Copyright:
© 2014 ISDN.

Funding

This work was supported in part by grants from the NIH ( National Institute on Drug Abuse , DA031604; DA013137 ; National Institute of Child Health and Human Development , HD043680 ) and the interdisciplinary graduate training program supported by the University of South Carolina Behavioral-Biomedical Interface Program. We thank Catherine B. Marcum, Marian Welch and Angela Clouse for assistance with data collection and Dr. Rosemarie M. Booze and Dr. Landhing M. Moran for critical readings of earlier drafts of the manuscript.

Funders	Funder number
University of South Carolina Behavioral-Biomedical Interface Program
National Institutes of Health (NIH)
National Institute on Drug Abuse	R03DA031604, DA013137
Eunice Kennedy Shriver National Institute of Child Health and Human Development	HD043680

Keywords

Drug abuse
Environmental agents
Polytocus
Prenatal growth
Rats
Uterine position

ASJC Scopus subject areas

Developmental Neuroscience
Developmental Biology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ijdevneu.2014.11.001

Cite this

@article{95afe384f55d44c79b6c78214ef7d979,

title = "Polytocus focus: Uterine position effect is dependent upon horn size",

abstract = "Understanding the variability caused by uterine position effects in polytocus species, such as rats, may enhance prenatal animal models for the study of drug and environmental agents. The primiparous litters of 42 intact female Sprague-Dawley rats were studied. Uterine position, fetal body weight, and fetal brain (wet) weight were recorded on gestation day (GD) 20 (GD 0. =. sperm positive). Uterine position effect for brain and body weight varied depending upon horn size. Furthermore, an inverse relationship between horn size (and, to a lesser extent, litter size) and fetal weight applied to both body and brain weight measures. There were no statistical differences in brain and body weights between the left and right uterine horns. The position of the uterine horn (left vs. right) and litter size did not influence the uterine position effect in the rat. Collectively, the present data suggest the presence of a significant uterine position effect. Prenatal differences based on uterine position provide an untapped opportunity to increase our understanding of developmental neurotoxicological and teratological studies that employ a polytocus species as an animal model.",

keywords = "Drug abuse, Environmental agents, Polytocus, Prenatal growth, Rats, Uterine position",

author = "McLaurin, \{Kristen A.\} and Mactutus, \{Charles F.\}",

note = "Publisher Copyright: {\textcopyright} 2014 ISDN.",

year = "2015",

month = feb,

day = "1",

doi = "10.1016/j.ijdevneu.2014.11.001",

language = "English",

volume = "40",

pages = "85--91",

}

TY - JOUR

T1 - Polytocus focus

T2 - Uterine position effect is dependent upon horn size

AU - McLaurin, Kristen A.

AU - Mactutus, Charles F.

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Understanding the variability caused by uterine position effects in polytocus species, such as rats, may enhance prenatal animal models for the study of drug and environmental agents. The primiparous litters of 42 intact female Sprague-Dawley rats were studied. Uterine position, fetal body weight, and fetal brain (wet) weight were recorded on gestation day (GD) 20 (GD 0. =. sperm positive). Uterine position effect for brain and body weight varied depending upon horn size. Furthermore, an inverse relationship between horn size (and, to a lesser extent, litter size) and fetal weight applied to both body and brain weight measures. There were no statistical differences in brain and body weights between the left and right uterine horns. The position of the uterine horn (left vs. right) and litter size did not influence the uterine position effect in the rat. Collectively, the present data suggest the presence of a significant uterine position effect. Prenatal differences based on uterine position provide an untapped opportunity to increase our understanding of developmental neurotoxicological and teratological studies that employ a polytocus species as an animal model.

AB - Understanding the variability caused by uterine position effects in polytocus species, such as rats, may enhance prenatal animal models for the study of drug and environmental agents. The primiparous litters of 42 intact female Sprague-Dawley rats were studied. Uterine position, fetal body weight, and fetal brain (wet) weight were recorded on gestation day (GD) 20 (GD 0. =. sperm positive). Uterine position effect for brain and body weight varied depending upon horn size. Furthermore, an inverse relationship between horn size (and, to a lesser extent, litter size) and fetal weight applied to both body and brain weight measures. There were no statistical differences in brain and body weights between the left and right uterine horns. The position of the uterine horn (left vs. right) and litter size did not influence the uterine position effect in the rat. Collectively, the present data suggest the presence of a significant uterine position effect. Prenatal differences based on uterine position provide an untapped opportunity to increase our understanding of developmental neurotoxicological and teratological studies that employ a polytocus species as an animal model.

KW - Drug abuse

KW - Environmental agents

KW - Polytocus

KW - Prenatal growth

KW - Rats

KW - Uterine position

UR - https://www.scopus.com/pages/publications/84919904059

UR - https://www.scopus.com/pages/publications/84919904059#tab=citedBy

U2 - 10.1016/j.ijdevneu.2014.11.001

DO - 10.1016/j.ijdevneu.2014.11.001

M3 - Article

C2 - 25447787

AN - SCOPUS:84919904059

SN - 0736-5748

VL - 40

SP - 85

EP - 91

JO - International Journal of Developmental Neuroscience

JF - International Journal of Developmental Neuroscience

ER -

Polytocus focus: Uterine position effect is dependent upon horn size

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this