TY - JOUR
T1 - Possible effects of some antipsychotic drugs on C-reactive protein in a drug-naïve psychotic sample
AU - Diaz, Francisco J.
AU - Pérez-Iglesias, Rocío
AU - Mata, Ignacio
AU - Martínez-Garcia, Obdulia
AU - Vázquez-Barquero, José L.
AU - de Leon, Jose
AU - Crespo-Facorro, Benedicto
PY - 2010/8
Y1 - 2010/8
N2 - Antipsychotic effects on C-reactive protein (CRP) have received little attention. This randomized open-label study investigated the possible effects of antipsychotics on CRP levels after 3 and 12. months of treatment in a Spanish drug-naïve sample taking haloperidol (N=36 after 3. months), olanzapine (N=36 after 3. months) or risperidone (N=39 after 3. months). After 3. months and adjusting for differences in baseline CRP levels, baseline smoking and high baseline triglyceride levels, patients on haloperidol treatment had CRP levels that were 92.7% higher than those of patients on risperidone treatment (p=0.009). After 12. months, only smoking was associated with increased CRP levels. Future studies need to verify that different antipsychotics may have differential effects on CRP levels, particularly after 3. months of treatment.
AB - Antipsychotic effects on C-reactive protein (CRP) have received little attention. This randomized open-label study investigated the possible effects of antipsychotics on CRP levels after 3 and 12. months of treatment in a Spanish drug-naïve sample taking haloperidol (N=36 after 3. months), olanzapine (N=36 after 3. months) or risperidone (N=39 after 3. months). After 3. months and adjusting for differences in baseline CRP levels, baseline smoking and high baseline triglyceride levels, patients on haloperidol treatment had CRP levels that were 92.7% higher than those of patients on risperidone treatment (p=0.009). After 12. months, only smoking was associated with increased CRP levels. Future studies need to verify that different antipsychotics may have differential effects on CRP levels, particularly after 3. months of treatment.
KW - C-reactive protein
KW - Haloperidol
KW - Metabolic syndrome
KW - Olanzapine
KW - Risperidone
KW - Schizophrenia
KW - Smoking
UR - http://www.scopus.com/inward/record.url?scp=77955058549&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77955058549&partnerID=8YFLogxK
U2 - 10.1016/j.schres.2010.06.002
DO - 10.1016/j.schres.2010.06.002
M3 - Article
C2 - 20580206
AN - SCOPUS:77955058549
SN - 0920-9964
VL - 121
SP - 207
EP - 212
JO - Schizophrenia Research
JF - Schizophrenia Research
IS - 1-3
ER -
