Possible effects of some antipsychotic drugs on C-reactive protein in a drug-naïve psychotic sample

Antipsychotic effects on C-reactive protein (CRP) have received little attention. This randomized open-label study investigated the possible effects of antipsychotics on CRP levels after 3 and 12. months of treatment in a Spanish drug-naïve sample taking haloperidol (N=36 after 3. months), olanzapine (N=36 after 3. months) or risperidone (N=39 after 3. months). After 3. months and adjusting for differences in baseline CRP levels, baseline smoking and high baseline triglyceride levels, patients on haloperidol treatment had CRP levels that were 92.7% higher than those of patients on risperidone treatment (p=0.009). After 12. months, only smoking was associated with increased CRP levels. Future studies need to verify that different antipsychotics may have differential effects on CRP levels, particularly after 3. months of treatment.