TY - JOUR
T1 - Post-mortem findings in Huntington’s deep brain stimulation
T2 - A moving target due to atrophy
AU - Vedam-Mai, Vinata
AU - Martinez-Ramirez, Daniel
AU - Hilliard, Justin D.
AU - Carbunaru, Samuel
AU - Yachnis, Anthony T.
AU - Bloom, Joshua
AU - Keeling, Peyton
AU - Awe, Lisa
AU - Foote, Kelly D.
AU - Okun, Michael S.
N1 - Publisher Copyright:
© 2016 Vedam-Mai et al.
PY - 2016/4/27
Y1 - 2016/4/27
N2 - Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson’s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington’s disease (HD). Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.
AB - Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson’s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington’s disease (HD). Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.
KW - Atrophy
KW - Chorea
KW - Deep brain stimulation
KW - Electrode design
KW - Histopathology
KW - Huntington’s disease
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U2 - 10.7916/D8ZP462H
DO - 10.7916/D8ZP462H
M3 - Article
AN - SCOPUS:85028050274
VL - 2016
JO - Tremor and Other Hyperkinetic Movements
JF - Tremor and Other Hyperkinetic Movements
ER -