Post-mortem findings in Huntington’s deep brain stimulation: A moving target due to atrophy

Vinata Vedam-Mai, Daniel Martinez-Ramirez, Justin D. Hilliard, Samuel Carbunaru, Anthony T. Yachnis, Joshua Bloom, Peyton Keeling, Lisa Awe, Kelly D. Foote, Michael S. Okun

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson’s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington’s disease (HD). Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.

Original languageEnglish
JournalTremor and Other Hyperkinetic Movements
Volume2016
DOIs
StatePublished - Apr 27 2016

Bibliographical note

Publisher Copyright:
© 2016 Vedam-Mai et al.

Keywords

  • Atrophy
  • Chorea
  • Deep brain stimulation
  • Electrode design
  • Histopathology
  • Huntington’s disease

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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