Post-mortem findings in Huntington’s deep brain stimulation: A moving target due to atrophy

Vinata Vedam-Mai; Daniel Martinez-Ramirez; Justin D. Hilliard; Samuel Carbunaru; Anthony T. Yachnis; Joshua Bloom; Peyton Keeling; Lisa Awe; Kelly D. Foote; Michael S. Okun

doi:10.7916/D8ZP462H

Post-mortem findings in Huntington’s deep brain stimulation: A moving target due to atrophy

Vinata Vedam-Mai, Daniel Martinez-Ramirez, Justin D. Hilliard, Samuel Carbunaru, Anthony T. Yachnis, Joshua Bloom, Peyton Keeling, Lisa Awe, Kelly D. Foote, Michael S. Okun

Neurosurgery

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson’s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington’s disease (HD). Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.

Original language	English
Journal	Tremor and Other Hyperkinetic Movements
Volume	2016
DOIs	https://doi.org/10.7916/D8ZP462H
State	Published - Apr 27 2016

Bibliographical note

Publisher Copyright:
© 2016 Vedam-Mai et al.

Funding

Funders	Funder number
National Institute of Nursing Research	R01NR014852

Keywords

Atrophy
Chorea
Deep brain stimulation
Electrode design
Histopathology
Huntington’s disease

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

Access to Document

10.7916/D8ZP462H

Cite this

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title = "Post-mortem findings in Huntington{\textquoteright}s deep brain stimulation: A moving target due to atrophy",

abstract = "Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson{\textquoteright}s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington{\textquoteright}s disease (HD). Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.",

keywords = "Atrophy, Chorea, Deep brain stimulation, Electrode design, Histopathology, Huntington{\textquoteright}s disease",

author = "Vinata Vedam-Mai and Daniel Martinez-Ramirez and Hilliard, {Justin D.} and Samuel Carbunaru and Yachnis, {Anthony T.} and Joshua Bloom and Peyton Keeling and Lisa Awe and Foote, {Kelly D.} and Okun, {Michael S.}",

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doi = "10.7916/D8ZP462H",

language = "English",

volume = "2016",

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T1 - Post-mortem findings in Huntington’s deep brain stimulation

T2 - A moving target due to atrophy

AU - Vedam-Mai, Vinata

AU - Martinez-Ramirez, Daniel

AU - Hilliard, Justin D.

AU - Carbunaru, Samuel

AU - Yachnis, Anthony T.

AU - Bloom, Joshua

AU - Keeling, Peyton

AU - Awe, Lisa

AU - Foote, Kelly D.

AU - Okun, Michael S.

PY - 2016/4/27

Y1 - 2016/4/27

N2 - Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson’s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington’s disease (HD). Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.

AB - Background: Deep brain stimulation (DBS) has been shown to be effective for Parkinson’s disease, essential tremor, and primary dystonia. However, mixed results have been reported in Huntington’s disease (HD). Case Report: A single case of HD DBS was identified from the University of Florida DBS Brain Tissue Network. The clinical presentation, evolution, surgical planning, DBS parameters, clinical outcomes, and brain pathological changes are summarized. Discussion: This case of HD DBS revealed that chorea may improve and be sustained. Minimal histopathological changes were noted around the DBS leads. Severe atrophy due to HD likely changed the DBS lead position relative to the internal capsule.

KW - Atrophy

KW - Chorea

KW - Deep brain stimulation

KW - Electrode design

KW - Histopathology

KW - Huntington’s disease

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Post-mortem findings in Huntington’s deep brain stimulation: A moving target due to atrophy

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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