Post-therapy iodine-131 localization in unsuspected large renal cyst: Possible mechanisms

Christopher Wen, Elaine Iuanow, Elizabeth Oates, Stephanie L. Lee, Ronald Perrone

Research output: Contribution to journalArticlepeer-review

29 Scopus citations


Sensitive and specific, whole-body 131I scintigraphy remains an important technique for diagnosing metastases from differentiated papillary or follicular thyroid carcinoma. False-positive 131I localization is well recognized and can occur in a variety of conditions. We present a case of intense 131I localization in a previously unsuspected large renal cyst; the lesion was not visualized on routine preablation diagnostic 131I scintigraphy but was obvious on posttherapeutic whole-body imaging, underscoring the value of posttherapy imaging in detecting abnormalities not apparent on diagnostic studies. Radioiodine within the urinary bladder or, at times, the renal collecting system is expected, because 131I excretion is primarily by glomerular filtration. In the case presented here, 131I activity within the renal cyst supports the concept that iodide is subject to an active secretory process by the renal tubule.

Original languageEnglish
Pages (from-to)2158-2161
Number of pages4
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Issue number12
StatePublished - Dec 1998


  • Iodine-131
  • Renal cyst
  • Thyroid carcinoma

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


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