Postoperative hyperthermia following off-pump versus on-pump coronary artery bypass surgery

Objective: Hyperthermia is common in the first 24 hours following coronary artery bypass graft surgery (CABG) with cardiopulmonary bypass (CPB). An inflammatory response to CPB is often implicated in the pathophysiology of this fever. Unlike CABG with CPB, the temperature pattern after off-pump CABG (OPCAB), where CPB is avoided, has not yet been described. The purpose of this study was to describe the postoperative temperature pattern following OPCAB and to compare it with that following on-pump cardiac surgery. Design: Retrospective, observational study. Setting: Tertiary care university hospital. Participants: Consenting patients undergoing CABG or OPCAB procedures. Interventions: Observational. Measurements and Main Results: Of the CABG patients, 89% had temperature elevations above 38°C, versus 44% of the OPCAB patients (P = 0.04). Peak body temperature was higher in the on-pump patients (CABG 38.5°C ± 0.4°C versus OPCAB 37.9°C ± 0.5°C; P = 0.002), as was the area under the curve for temperatures greater than 38°C (CABG 1.6 ± 1.7°C/hr versus OPCAB 0.4 ± 1.2°C/hr; P = 0.02). Conclusions: Off-pump CABG surgery patients experience less hyperthermia compared with on-pump CABG patients. The reasons for a lower incidence and severity of hyperthermia after OPCAB surgery are not known, but may be related to a reduced inflammatory response.