Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains

Robert F. Hunt; Laura A. Haselhorst; Kathleen M. Schoch; Eva C. Bach; Jennifer Rios-Pilier; Stephen W. Scheff; Kathryn E. Saatman; Bret N. Smith

doi:10.1016/j.eplepsyres.2011.10.011

Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains

Robert F. Hunt
, Laura A. Haselhorst
, Kathleen M. Schoch
, Eva C. Bach
, Jennifer Rios-Pilier
, Stephen W. Scheff
, Kathryn E. Saatman
, Bret N. Smith

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.

Original language	English
Pages (from-to)	167-170
Number of pages	4
Journal	Epilepsy Research
Volume	99
Issue number	1-2
DOIs	https://doi.org/10.1016/j.eplepsyres.2011.10.011
State	Published - Mar 2012

Bibliographical note

Funding Information:
This research was supported by NIH NS052302 and USAMRMC W81XWH-11-1-0502 to B.N.S., NIH AG21981 to S.W.S., NIH P01 NS058484 to K.E.S., and an Epilepsy Foundation Training Fellowship to R.F.H.

Funding

This research was supported by NIH NS052302 and USAMRMC W81XWH-11-1-0502 to B.N.S., NIH AG21981 to S.W.S., NIH P01 NS058484 to K.E.S., and an Epilepsy Foundation Training Fellowship to R.F.H.

Funders	Funder number
National Institutes of Health (NIH)	NS052302
Institute of Neurological Disorders and Stroke National Advisory Neurological Disorders and Stroke Council	P01NS058484
Army Medical Research and Materiel Command	P01 NS058484, AG21981, W81XWH-11-1-0502

Keywords

Contusion
Dentate gyrus
Epilepsy model
Epileptogenesis
Seizure
Traumatic brain injury

ASJC Scopus subject areas

Neurology
Clinical Neurology

Access to Document

10.1016/j.eplepsyres.2011.10.011

Cite this

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title = "Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains",

abstract = "Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.",

keywords = "Contusion, Dentate gyrus, Epilepsy model, Epileptogenesis, Seizure, Traumatic brain injury",

author = "Hunt, \{Robert F.\} and Haselhorst, \{Laura A.\} and Schoch, \{Kathleen M.\} and Bach, \{Eva C.\} and Jennifer Rios-Pilier and Scheff, \{Stephen W.\} and Saatman, \{Kathryn E.\} and Smith, \{Bret N.\}",

note = "Funding Information: This research was supported by NIH NS052302 and USAMRMC W81XWH-11-1-0502 to B.N.S., NIH AG21981 to S.W.S., NIH P01 NS058484 to K.E.S., and an Epilepsy Foundation Training Fellowship to R.F.H.",

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AU - Bach, Eva C.

AU - Rios-Pilier, Jennifer

AU - Scheff, Stephen W.

AU - Saatman, Kathryn E.

AU - Smith, Bret N.

N1 - Funding Information: This research was supported by NIH NS052302 and USAMRMC W81XWH-11-1-0502 to B.N.S., NIH AG21981 to S.W.S., NIH P01 NS058484 to K.E.S., and an Epilepsy Foundation Training Fellowship to R.F.H.

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N2 - Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.

AB - Controlled cortical impact injury was used to examine relationships between focal posttraumatic cortical damage and mossy fiber sprouting (MFS) in the dentate gyrus in three mouse strains. Posttraumatic MFS was more robust when cortical injury impinged upon the hippocampus, versus contusions restricted to neocortex, and was qualitatively similar among CD-1, C57BL/6, and FVB/N background strains. Impact parameters influencing injury severity may be critical in reproducing epilepsy-related changes in neurotrauma models.

KW - Contusion

KW - Dentate gyrus

KW - Epilepsy model

KW - Epileptogenesis

KW - Seizure

KW - Traumatic brain injury

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Posttraumatic mossy fiber sprouting is related to the degree of cortical damage in three mouse strains

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

Access to Document

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Cite this