Abstract: This paper is the outcome of the fourth UC Davis Systems Approach to Understanding Cardiac Excitation–Contraction Coupling and Arrhythmias Symposium, a biannual event that aims to bring together leading experts in subfields of cardiovascular biomedicine to focus on topics of importance to the field. The theme of the 2016 symposium was ‘K+ Channels and Regulation’. Experts in the field contributed their experimental and mathematical modelling perspectives and discussed emerging questions, controversies and challenges on the topic of cardiac K+ channels. This paper summarizes the topics of formal presentations and informal discussions from the symposium on the structural basis of voltage-gated K+ channel function, as well as the mechanisms involved in regulation of K+ channel gating, expression and membrane localization. Given the critical role for K+ channels in determining the rate of cardiac repolarization, it is hardly surprising that essentially every aspect of K+ channel function is exquisitely regulated in cardiac myocytes. This regulation is complex and highly interrelated to other aspects of myocardial function. K+ channel regulatory mechanisms alter, and are altered by, physiological challenges, pathophysiological conditions, and pharmacological agents. An accompanying paper focuses on the integrative role of K+ channels in cardiac electrophysiology, i.e. how K+ currents shape the cardiac action potential, and how their dysfunction can lead to arrhythmias, and discusses K+ channel-based therapeutics. A fundamental understanding of K+ channel regulatory mechanisms and disease processes is fundamental to reveal new targets for human therapy.
|Number of pages||20|
|Journal||Journal of Physiology|
|State||Published - Apr 1 2017|
Bibliographical noteFunding Information:
This conference was supported by the National Institutes of Health (NIH) R13HL132515 grant to Y.C.-I., D.M.B., N.C. and E.G., R01HL131517 grant to E.G., American Heart Association (15SDG24910015 to E.G.) and additional grants to other authors that allowed them to participate. We also thank many sponsors that support the University of California Davis Cardiovascular Symposium Series. See the conference website for detailed information. We thank the Organizing Committee, Consultants, and all conference participants for their contributions to the scientific exchange and discussions. For conference information see basicscience.ucdmc.ucdavis.edu/UCDavisCardiovascularSymposia/index.html.
© 2016 The Authors. The Journal of Physiology © 2016 The Physiological Society
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