Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif

Kevin J. Frankowski, Stephen R. Slauson, Kimberly M. Lovell, Angela M. Phillips, John M. Streicher, Lei Zhou, David A. Whipple, Frank J. Schoenen, Thomas E. Prisinzano, Laura M. Bohn, Jeffrey Aubé

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Pharmacology, Toxicology and Pharmaceutical Science

Chemistry