Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo

Huarong Huang, Yan He, Xiao Xing Cui, Susan Goodin, Hong Wang, Zhi Yun Du, Dongli Li, Kun Zhang, Ah Ng Tony Kong, Robert S. Dipaola, Chung S. Yang, Allan H. Conney, Xi Zheng

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

In the present study, the effects of β-tocopherol (β-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of Δ-tocopherol (Δ-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with β-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of Δ-T were modest. The strong effects of β-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that β-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of Δ-T. Moreover, β-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified β-T as a better form of vitamin E than Δ-T for future clinical studies of prostate cancer prevention.

Original languageEnglish
Pages (from-to)10752-10758
Number of pages7
JournalJournal of Agricultural and Food Chemistry
Volume62
Issue number44
DOIs
StatePublished - Nov 5 2014

Bibliographical note

Publisher Copyright:
© 2014 American Chemical Society.

Keywords

  • AR signaling
  • apoptosis
  • prostate cancer
  • tocopherol
  • vitamin E
  • xenograft tumor

ASJC Scopus subject areas

  • Chemistry (all)
  • Agricultural and Biological Sciences (all)

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