Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo

Huarong Huang; Yan He; Xiao Xing Cui; Susan Goodin; Hong Wang; Zhi Yun Du; Dongli Li; Kun Zhang; Ah Ng Tony Kong; Robert S. Dipaola; Chung S. Yang; Allan H. Conney; Xi Zheng

doi:10.1021/jf504058f

Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo

Huarong Huang, Yan He, Xiao Xing Cui, Susan Goodin, Hong Wang, Zhi Yun Du, Dongli Li, Kun Zhang, Ah Ng Tony Kong, Robert S. Dipaola, Chung S. Yang, Allan H. Conney, Xi Zheng

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

In the present study, the effects of β-tocopherol (β-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of Δ-tocopherol (Δ-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with β-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of Δ-T were modest. The strong effects of β-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that β-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of Δ-T. Moreover, β-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified β-T as a better form of vitamin E than Δ-T for future clinical studies of prostate cancer prevention.

Original language	English
Pages (from-to)	10752-10758
Number of pages	7
Journal	Journal of Agricultural and Food Chemistry
Volume	62
Issue number	44
DOIs	https://doi.org/10.1021/jf504058f
State	Published - Nov 5 2014

Bibliographical note

Publisher Copyright:
© 2014 American Chemical Society.

Funding

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	P30CA072720
National Childhood Cancer Registry – National Cancer Institute

Keywords

AR signaling
apoptosis
prostate cancer
tocopherol
vitamin E
xenograft tumor

ASJC Scopus subject areas

General Chemistry
General Agricultural and Biological Sciences

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/jf504058f

Cite this

Huang, H., He, Y., Cui, X. X., Goodin, S., Wang, H., Du, Z. Y., Li, D., Zhang, K., Tony Kong, A. N., Dipaola, R. S., Yang, C. S., Conney, A. H., & Zheng, X. (2014). Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo. Journal of Agricultural and Food Chemistry, 62(44), 10752-10758. https://doi.org/10.1021/jf504058f

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title = "Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo",

abstract = "In the present study, the effects of β-tocopherol (β-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of Δ-tocopherol (Δ-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with β-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of Δ-T were modest. The strong effects of β-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that β-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of Δ-T. Moreover, β-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified β-T as a better form of vitamin E than Δ-T for future clinical studies of prostate cancer prevention.",

keywords = "AR signaling, apoptosis, prostate cancer, tocopherol, vitamin E, xenograft tumor",

author = "Huarong Huang and Yan He and Cui, \{Xiao Xing\} and Susan Goodin and Hong Wang and Du, \{Zhi Yun\} and Dongli Li and Kun Zhang and \{Tony Kong\}, \{Ah Ng\} and Dipaola, \{Robert S.\} and Yang, \{Chung S.\} and Conney, \{Allan H.\} and Xi Zheng",

note = "Publisher Copyright: {\textcopyright} 2014 American Chemical Society.",

year = "2014",

month = nov,

day = "5",

doi = "10.1021/jf504058f",

language = "English",

volume = "62",

pages = "10752--10758",

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Huang, H, He, Y, Cui, XX, Goodin, S, Wang, H, Du, ZY, Li, D, Zhang, K, Tony Kong, AN, Dipaola, RS, Yang, CS, Conney, AH & Zheng, X 2014, 'Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo', Journal of Agricultural and Food Chemistry, vol. 62, no. 44, pp. 10752-10758. https://doi.org/10.1021/jf504058f

TY - JOUR

T1 - Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo

AU - Huang, Huarong

AU - He, Yan

AU - Cui, Xiao Xing

AU - Goodin, Susan

AU - Wang, Hong

AU - Du, Zhi Yun

AU - Li, Dongli

AU - Zhang, Kun

AU - Tony Kong, Ah Ng

AU - Dipaola, Robert S.

AU - Yang, Chung S.

AU - Conney, Allan H.

AU - Zheng, Xi

PY - 2014/11/5

Y1 - 2014/11/5

N2 - In the present study, the effects of β-tocopherol (β-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of Δ-tocopherol (Δ-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with β-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of Δ-T were modest. The strong effects of β-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that β-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of Δ-T. Moreover, β-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified β-T as a better form of vitamin E than Δ-T for future clinical studies of prostate cancer prevention.

AB - In the present study, the effects of β-tocopherol (β-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of Δ-tocopherol (Δ-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with β-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of Δ-T were modest. The strong effects of β-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that β-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of Δ-T. Moreover, β-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified β-T as a better form of vitamin E than Δ-T for future clinical studies of prostate cancer prevention.

KW - AR signaling

KW - apoptosis

KW - prostate cancer

KW - tocopherol

KW - vitamin E

KW - xenograft tumor

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AN - SCOPUS:84908577122

SN - 0021-8561

VL - 62

SP - 10752

EP - 10758

JO - Journal of Agricultural and Food Chemistry

JF - Journal of Agricultural and Food Chemistry

IS - 44

ER -

Potent inhibitory effect of β-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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