Radiotherapy is a mainstay of treatment for head and neck cancer. However, the morbidity of treatment remains a clinical challenge. Molecular profiling has provided further insight into tumor biology and tumor sensitivity to radiation, and this information could be used to personalize treatment. In this review, we discuss published signatures of radiosensitivity and discuss the pathways that may be important in dictating radiation sensitivity. Applications of these signatures could result in less morbidity if dose de-escalation efforts are successful.
|Journal||Annals of Translational Medicine|
|State||Published - Dec 2016|
Bibliographical notePublisher Copyright:
© Annals of Translational Medicine. All rights reserved.
- Epithelial-mesenchymal transition (EMT)
- Head and neck cancer
- Radiation sensitivity
ASJC Scopus subject areas
- Medicine (all)