Potential cytochrome P-450 drug-drug interactions in adults with metastatic solid tumors and effect on eligibility for Phase I clinical trials

Kari B. Wisinski, Colby A. Cantu, Jens Eickhoff, Kurt Osterby, Amye J. Tevaarwerk, Jennifer Heideman, Glenn Liu, George Wilding, Susan Johnston, Jill M. Kolesar

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Purpose. Potential cytochrome P-450 (CYP) drug-drug interactions in adults with metastatic solid tumors and their effect on eligibility for Phase I clinical trials were characterized. Methods. This study included adult patients with metastatic solid tumors seen by a medical oncologist from January 2008 through July 2011. The medications used by these patients were identified. Each medication's potential for interacting with CYP isozymes was also characterized. Medication changes required to meet Phase I trial eligibility criteria were also reviewed. Results. Data from 1773 patients were analyzed: 1489 were not enrolled in a Phase I trial and 284 were enrolled in a Phase I trial. Polypharmacy was significantly more prevalent in the group enrolled in a Phase I trial compared with those not enrolled (95% versus 80%, p < 0.001). The majority of patients not enrolled in a Phase I trial were taking at least one CYP isozyme inhibitor (87%) and at least one CYP isozyme inducer (45%). In a separate analysis, four Phase I trials were evaluated. Of 295 screened patients, 3.2% could not enroll due to concurrent medications. Charts from 74 enrolled patients revealed 655 concurrent medications-93 medications required further review for eligibility involving 51 (69%) of patients. Of the 93 medications, 38 (41%) were stopped and 41 (44%) were changed for the study. Conclusion. Polypharmacy and the use of medications that interact with CYP isoyzmes were common in adult patients with metastatic solid tumors. Patients enrolling in Phase I studies often require medication changes to meet eligibility requirements.

Original languageEnglish
Pages (from-to)958-965
Number of pages8
JournalAmerican Journal of Health-System Pharmacy
Volume72
Issue number11
DOIs
StatePublished - Jun 1 2015

Bibliographical note

Publisher Copyright:
© 2015, American Society of Health-System Pharmacists, Inc. All rights reserved.

ASJC Scopus subject areas

  • Pharmacology
  • Health Policy

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