Potentiation of morphine-elicited circling by dopaminergic uptake blockade

Alain Gratton, Barry J. Hoffer, Greg A. Gerhardt, Roy A. Wise

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Contraversive circling induced by unilateral infusions of morphine (7.5 nanomoles or 5 μg) into the ventral tegmental area was studied under conditions of dopamine uptake inhibition. Dopamine uptake blockade with either nomifensine (2.5 mg/kg) or GBR 13069 (2.0 mg/kg) resulted in a 3-fold increase in the rate of circling. Naloxone (1.5 mg/kg) attenuated but did not completely block the potentiated circling. These data are consistent with the hypothesis that morphine causes contraversive circling through local activation or disinhibition of dopaminergic cell firing.

Original languageEnglish
Pages (from-to)1077-1079
Number of pages3
JournalPharmacology Biochemistry and Behavior
Volume30
Issue number4
DOIs
StatePublished - Aug 1988

Bibliographical note

Funding Information:
Supported by NSERC of Canada and by USPHS grants DA02429, NS09199 and AG06434. Special thanks to Dr. Richard Heikkila for generously providing the GBR-13069.

Keywords

  • Circling
  • Dopamine
  • GBR-13069
  • Morphine
  • Nomifensive

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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