Potentiation of morphine-elicited circling by dopaminergic uptake blockade

Alain Gratton; Barry J. Hoffer; Greg A. Gerhardt; Roy A. Wise

doi:10.1016/0091-3057(88)90142-6

Potentiation of morphine-elicited circling by dopaminergic uptake blockade

Alain Gratton, Barry J. Hoffer, Greg A. Gerhardt, Roy A. Wise

Research output: Contribution to journal › Article › peer-review

Abstract

Contraversive circling induced by unilateral infusions of morphine (7.5 nanomoles or 5 μg) into the ventral tegmental area was studied under conditions of dopamine uptake inhibition. Dopamine uptake blockade with either nomifensine (2.5 mg/kg) or GBR 13069 (2.0 mg/kg) resulted in a 3-fold increase in the rate of circling. Naloxone (1.5 mg/kg) attenuated but did not completely block the potentiated circling. These data are consistent with the hypothesis that morphine causes contraversive circling through local activation or disinhibition of dopaminergic cell firing.

Original language	English
Pages (from-to)	1077-1079
Number of pages	3
Journal	Pharmacology Biochemistry and Behavior
Volume	30
Issue number	4
DOIs	https://doi.org/10.1016/0091-3057(88)90142-6
State	Published - Aug 1988

Bibliographical note

Funding Information:
Supported by NSERC of Canada and by USPHS grants DA02429, NS09199 and AG06434. Special thanks to Dr. Richard Heikkila for generously providing the GBR-13069.

Keywords

Circling
Dopamine
GBR-13069
Morphine
Nomifensive

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(88)90142-6

Cite this

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abstract = "Contraversive circling induced by unilateral infusions of morphine (7.5 nanomoles or 5 μg) into the ventral tegmental area was studied under conditions of dopamine uptake inhibition. Dopamine uptake blockade with either nomifensine (2.5 mg/kg) or GBR 13069 (2.0 mg/kg) resulted in a 3-fold increase in the rate of circling. Naloxone (1.5 mg/kg) attenuated but did not completely block the potentiated circling. These data are consistent with the hypothesis that morphine causes contraversive circling through local activation or disinhibition of dopaminergic cell firing.",

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doi = "10.1016/0091-3057(88)90142-6",

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AU - Hoffer, Barry J.

AU - Gerhardt, Greg A.

AU - Wise, Roy A.

N1 - Funding Information: Supported by NSERC of Canada and by USPHS grants DA02429, NS09199 and AG06434. Special thanks to Dr. Richard Heikkila for generously providing the GBR-13069.

PY - 1988/8

Y1 - 1988/8

N2 - Contraversive circling induced by unilateral infusions of morphine (7.5 nanomoles or 5 μg) into the ventral tegmental area was studied under conditions of dopamine uptake inhibition. Dopamine uptake blockade with either nomifensine (2.5 mg/kg) or GBR 13069 (2.0 mg/kg) resulted in a 3-fold increase in the rate of circling. Naloxone (1.5 mg/kg) attenuated but did not completely block the potentiated circling. These data are consistent with the hypothesis that morphine causes contraversive circling through local activation or disinhibition of dopaminergic cell firing.

AB - Contraversive circling induced by unilateral infusions of morphine (7.5 nanomoles or 5 μg) into the ventral tegmental area was studied under conditions of dopamine uptake inhibition. Dopamine uptake blockade with either nomifensine (2.5 mg/kg) or GBR 13069 (2.0 mg/kg) resulted in a 3-fold increase in the rate of circling. Naloxone (1.5 mg/kg) attenuated but did not completely block the potentiated circling. These data are consistent with the hypothesis that morphine causes contraversive circling through local activation or disinhibition of dopaminergic cell firing.

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KW - Morphine

KW - Nomifensive

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Potentiation of morphine-elicited circling by dopaminergic uptake blockade

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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