Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities

Jose de Leon, Brian Greenlee, Jack Barber, Mohamed Sabaawi, Nirbhay N. Singh

Research output: Contribution to journalReview articlepeer-review

48 Scopus citations

Abstract

New generation antipsychotic (NGA) drugs introduced to the US market after clozapine (aripiprazole, olanzapine, paliperidone, quetiapine, risperidone, and ziprasidone) are frequently used in individuals with intellectual disabilities (ID). However, there is very limited research to fully establish evidence-based or personalized medicine approaches for their use in this population. These guidelines take a pragmatic approach to establishing frameworks for their use by utilizing the prescribing information and reviewing the available literature on other relevant neuropsychiatric disorders. In the absence of expert consensus guidance and well-controlled comparison trials, we present a set of guidelines to inform initiation, dosing and monitoring of use in adults. Further, in these guidelines we provide practical information on drug-drug interactions and adverse drug reactions, and a brief review of discontinuation syndromes, potential for abuse, use during pregnancy and cost considerations. We also provide drug utilization review forms for each NGA to facilitate implementation of these guidelines, these guidelines provide a practical and necessary resource for practitioners treating psychiatric disorders and challenging behaviors in adult individuals with ID.

Original languageEnglish
Pages (from-to)613-669
Number of pages57
JournalResearch in Developmental Disabilities
Volume30
Issue number4
DOIs
StatePublished - Jul 2009

Keywords

  • Antipsychotic medication
  • Aripiprazole
  • Individuals with intellectual disabilities
  • Olanzapine
  • Paliperidone
  • Quetiapine
  • Risperidone
  • Ziprasidone

ASJC Scopus subject areas

  • Developmental and Educational Psychology
  • Clinical Psychology

Fingerprint

Dive into the research topics of 'Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities'. Together they form a unique fingerprint.

Cite this