Preconcentration and analysis of trace volatile carbonyl compounds

Mingxiao Li; Souvik Biswas; Michael H. Nantz; Richard M. Higashi; Xiao An Fu

doi:10.1021/ac2021757

Preconcentration and analysis of trace volatile carbonyl compounds

Mingxiao Li, Souvik Biswas, Michael H. Nantz, Richard M. Higashi, Xiao An Fu

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43 Scopus citations

Abstract

We describe a preconcentration device that may be suitable for quantitative analysis of trace volatile ketones and aldehydes in ambient air as well as in human breath. The approach is based on microreactor chips fabricated from silicon wafers. The microreactors have thousands of micropillars in microfluidic channels for uniformly distributing a gaseous sample flowing through the chips. The surfaces of the micropillars are functionalized with a quaternary ammonium aminooxy salt, [2-(aminooxy)ethyl]-N,N,N-trimethylammonium iodide (ATM), for trapping trace ketones and aldehydes by means of oximation reactions. ATM adducts and unreacted ATM are eluted from the microreactor with less than 40 μL of methanol and directly analyzed by nanospray Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS). Ketones and aldehydes at levels of 1 ppbv have been detected using this microreactor and FTICR-MS system.

Original language	English
Pages (from-to)	1288-1293
Number of pages	6
Journal	Analytical Chemistry
Volume	84
Issue number	3
DOIs	https://doi.org/10.1021/ac2021757
State	Published - Feb 7 2012

Bibliographical note

Funding Information:
ment were provided by R. Shiono. supported by National Institutes GM-25672.

ASJC Scopus subject areas

Analytical Chemistry

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10.1021/ac2021757

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title = "Preconcentration and analysis of trace volatile carbonyl compounds",

abstract = "We describe a preconcentration device that may be suitable for quantitative analysis of trace volatile ketones and aldehydes in ambient air as well as in human breath. The approach is based on microreactor chips fabricated from silicon wafers. The microreactors have thousands of micropillars in microfluidic channels for uniformly distributing a gaseous sample flowing through the chips. The surfaces of the micropillars are functionalized with a quaternary ammonium aminooxy salt, [2-(aminooxy)ethyl]-N,N,N-trimethylammonium iodide (ATM), for trapping trace ketones and aldehydes by means of oximation reactions. ATM adducts and unreacted ATM are eluted from the microreactor with less than 40 μL of methanol and directly analyzed by nanospray Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS). Ketones and aldehydes at levels of 1 ppbv have been detected using this microreactor and FTICR-MS system.",

author = "Mingxiao Li and Souvik Biswas and Nantz, {Michael H.} and Higashi, {Richard M.} and Fu, {Xiao An}",

note = "Funding Information: ment were provided by R. Shiono. supported by National Institutes GM-25672.",

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T1 - Preconcentration and analysis of trace volatile carbonyl compounds

AU - Li, Mingxiao

AU - Biswas, Souvik

AU - Nantz, Michael H.

AU - Higashi, Richard M.

AU - Fu, Xiao An

N1 - Funding Information: ment were provided by R. Shiono. supported by National Institutes GM-25672.

PY - 2012/2/7

Y1 - 2012/2/7

N2 - We describe a preconcentration device that may be suitable for quantitative analysis of trace volatile ketones and aldehydes in ambient air as well as in human breath. The approach is based on microreactor chips fabricated from silicon wafers. The microreactors have thousands of micropillars in microfluidic channels for uniformly distributing a gaseous sample flowing through the chips. The surfaces of the micropillars are functionalized with a quaternary ammonium aminooxy salt, [2-(aminooxy)ethyl]-N,N,N-trimethylammonium iodide (ATM), for trapping trace ketones and aldehydes by means of oximation reactions. ATM adducts and unreacted ATM are eluted from the microreactor with less than 40 μL of methanol and directly analyzed by nanospray Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS). Ketones and aldehydes at levels of 1 ppbv have been detected using this microreactor and FTICR-MS system.

AB - We describe a preconcentration device that may be suitable for quantitative analysis of trace volatile ketones and aldehydes in ambient air as well as in human breath. The approach is based on microreactor chips fabricated from silicon wafers. The microreactors have thousands of micropillars in microfluidic channels for uniformly distributing a gaseous sample flowing through the chips. The surfaces of the micropillars are functionalized with a quaternary ammonium aminooxy salt, [2-(aminooxy)ethyl]-N,N,N-trimethylammonium iodide (ATM), for trapping trace ketones and aldehydes by means of oximation reactions. ATM adducts and unreacted ATM are eluted from the microreactor with less than 40 μL of methanol and directly analyzed by nanospray Fourier transform ion cyclotron resonance (FTICR) mass spectrometry (MS). Ketones and aldehydes at levels of 1 ppbv have been detected using this microreactor and FTICR-MS system.

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JO - Analytical Chemistry

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ER -

Preconcentration and analysis of trace volatile carbonyl compounds

Abstract

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ASJC Scopus subject areas

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