TY - JOUR
T1 - Predicting substance use disorder using long-term attention deficit hyperactivity disorder medication records in Truven
AU - Fouladvand, Sajjad
AU - Hankosky, Emily R.
AU - Bush, Heather
AU - Chen, Jin
AU - Dwoskin, Linda P.
AU - Freeman, Patricia R.
AU - Henderson, Darren W.
AU - Kantak, Kathleen
AU - Talbert, Jeffery
AU - Tao, Shiqiang
AU - Zhang, Guo Qiang
N1 - Publisher Copyright:
© The Author(s) 2019.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - About 20% of individuals with attention deficit hyperactivity disorder are first diagnosed during adolescence. While preclinical experiments suggest that adolescent-onset exposure to attention deficit hyperactivity disorder medication is an important factor in the development of substance use disorder phenotypes in adulthood, the long-term impact of attention deficit hyperactivity disorder medication initiated during adolescence has been largely unexplored in humans. Our analysis of 11,624 adolescent enrollees with attention deficit hyperactivity disorder in the Truven database indicates that temporal medication features, rather than stationary features, are the most important factors on the health consequences related to substance use disorder and attention deficit hyperactivity disorder medication initiation during adolescence.
AB - About 20% of individuals with attention deficit hyperactivity disorder are first diagnosed during adolescence. While preclinical experiments suggest that adolescent-onset exposure to attention deficit hyperactivity disorder medication is an important factor in the development of substance use disorder phenotypes in adulthood, the long-term impact of attention deficit hyperactivity disorder medication initiated during adolescence has been largely unexplored in humans. Our analysis of 11,624 adolescent enrollees with attention deficit hyperactivity disorder in the Truven database indicates that temporal medication features, rather than stationary features, are the most important factors on the health consequences related to substance use disorder and attention deficit hyperactivity disorder medication initiation during adolescence.
KW - attention deficit hyperactivity disorder
KW - big data
KW - deep learning
KW - long-short term memory model
KW - substance use disorder
UR - http://www.scopus.com/inward/record.url?scp=85088100178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85088100178&partnerID=8YFLogxK
U2 - 10.1177/1460458219844075
DO - 10.1177/1460458219844075
M3 - Article
C2 - 31106686
AN - SCOPUS:85088100178
SN - 1460-4582
VL - 26
SP - 787
EP - 802
JO - Health Informatics Journal
JF - Health Informatics Journal
IS - 2
ER -