Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

G. Yu; T. Durduran; C. Zhou; M. Putt; A. G. Yodh; T. M. Busch

Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

G. Yu, T. Durduran, C. Zhou, M. Putt, A. G. Yodh, T. M. Busch

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

Abstract

A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.

Original language	English
Title of host publication	Biomedical Topical Meeting, BIOMED 2004
ISBN (Electronic)	1557527695
State	Published - 2004
Event	Biomedical Topical Meeting, BIOMED 2004 - Miami Beach, United States Duration: Apr 14 2004 → Apr 17 2004

Publication series

Name	Optics InfoBase Conference Papers
ISSN (Electronic)	2162-2701

Conference

Conference	Biomedical Topical Meeting, BIOMED 2004
Country/Territory	United States
City	Miami Beach
Period	4/14/04 → 4/17/04

Bibliographical note

Publisher Copyright:
© 2004 Optical Society of America

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Mechanics of Materials

Cite this

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title = "Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors",

abstract = "A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.",

author = "G. Yu and T. Durduran and C. Zhou and M. Putt and Yodh, {A. G.} and Busch, {T. M.}",

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year = "2004",

language = "English",

series = "Optics InfoBase Conference Papers",

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T1 - Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

AU - Yu, G.

AU - Durduran, T.

AU - Zhou, C.

AU - Putt, M.

AU - Yodh, A. G.

AU - Busch, T. M.

PY - 2004

Y1 - 2004

N2 - A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.

AB - A diffuse correlation spectroscopy (DCS) is used to non-invasively measure in vivo blood flow responses to PDT in mice bearing radiation-induced fibrosarcoma (RIF) tumors. The treatment efficacy, as measured by the tumor regrowth time, significantly correlates with the acute flow reduction rate during PDT, as well as with flow reduction 3 hours after PDT. We surmise from this data that rapid vascular occlusion during PDT shuts off the tissue oxygen supply which in turn reduces PDT efficacy, and greater reduction of blood flow at 3 hours after PDT demonstrates more vascular damage which correlates good treatment efficacy.

UR - http://www.scopus.com/inward/record.url?scp=85134596310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85134596310&partnerID=8YFLogxK

M3 - Conference contribution

AN - SCOPUS:85134596310

T3 - Optics InfoBase Conference Papers

BT - Biomedical Topical Meeting, BIOMED 2004

T2 - Biomedical Topical Meeting, BIOMED 2004

Y2 - 14 April 2004 through 17 April 2004

ER -

Prediction of Treatment Efficacy by Blood Flow Responses to PDT in RIF Tumors

Abstract

Publication series

Conference

Bibliographical note

ASJC Scopus subject areas

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