Predictors for 30-Day and 90-Day Hospital Readmission Among Patients With Opioid Use Disorder

Jessica L. Moreno, Sarah E. Wakeman, Matthew S. Duprey, Russell J. Roberts, Jared S. Jacobson, John W. Devlin

Research output: Contribution to journalArticlepeer-review


Objectives: To identify the incidence, characteristics, and predictors for 30 and 90-day readmission among acutely hospitalized patients with opioid use disorder (OUD). Methods: This retrospective, cohort study evaluated consecutive adults with OUD admitted to an academic medical center over a 5-year period (10/1/11 to 9/30/16). Multivariable logistic regression was used to determine independent predictors for 30 and 90-day readmissions based on pertinent admission, hospital, and discharge variables collected via chart review and found to be different (with a P<0.10) on univariate analysis. Results: Among the 470 adults (mean age 43.1±12.8 years, past heroin use 77.9%; admission opioid agonist therapy use [buprenorphine 22.6%; methadone 27.0%]; medical [vs surgical] admission 75.3%, floor [vs ICU] admission 93.0%, in-hospital mortality 0.9%), 85 (18.2%) and 151 (32.1%) were readmitted within 30 and 90 days, respectively. Among the 90-day readmitted patients, median time to first readmission was 26 days. Buprenorphine use (vs no use) at index hospital admission was independently associated with reduced 30- day (odds ratio [OR] 0.47, 95% confidence interval [CI] 0.24-0.93) and 90-day (OR 0.57, 95% CI 0.34-0.96) readmission; prior heroin (vs prescription opioid) use was associated with reduced 90-day readmission (OR 0.59, 95% CI 0.37-0.94) and length of hospital stay was associated with both greater 30-day (OR 1.02, 95% CI 1.01- 1.05) and 90-day (OR 1.04, 95% CI 1.01-1.06) readmission rates. Conclusions: Among patients with OUD taking buprenorphine at the time of hospital admission, 30-day and 90-day hospital readmission was reduced by 53% and 43%, respectively.

Original languageEnglish
Pages (from-to)306-313
Number of pages8
JournalJournal of Addiction Medicine
Issue number6
StatePublished - Nov 1 2018

Bibliographical note

Publisher Copyright:
Copyright © 2018 American Society of Addiction Medicine.


  • Buprenorphine
  • Opioid agonist treatment
  • Opioid use disorder
  • Opioids
  • Readmission

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Pharmacology (medical)


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