Predictors of cognitive decline after cardiac operation

Mark F. Newman, Narda D. Croughwell, James A. Blumenthal, Edward Lowry, William D. White, William Spillane, R. Duane Davis, Donald D. Glower, Lloyd R. Smith, Elizabeth P. Mahanna, Joseph G. Reves

Research output: Contribution to journalArticlepeer-review

199 Scopus citations


Despite major advances in cardiopulmonary bypass technology, surgical techniques, and anesthesia management, central nervous system complications remain a common problem after cardiopulmonary bypass. The etiology of neuropsychologic dysfunction after cardiopulmonary bypass remains unresolved and is probably multifactorial. Demographic predictors of cognitive decline include age and years of education; perioperative factors including number of cerebral emboli, temperature, mean arterial pressure, and jugular bulb oxygen saturation have varying predictive power. Recent data suggest a genetic predisposition for cognitive decline after cardiac surgery in patients possessing the apolipoprotein E -4 allele, known to be associated with late-onset and sporadic forms of Alzheimer's disease. Predicting patients at risk for cognitive decline allows the possibility of many important interventions. Predictive power and weapons to reduce cellular injury associated with neurologic insults lend hope of a future ability to markedly decrease the impact of cardiopulmonary bypass on short-term and long-term neurologic, cognitive, and quality-of-life outcomes.

Original languageEnglish
Pages (from-to)1326-1330
Number of pages5
JournalAnnals of Thoracic Surgery
Issue number5
StatePublished - May 1995

Bibliographical note

Funding Information:
This research was supported by grant RO1-AG09663 from the National Institutes of Health and a grant from the Anesthesia Patient Safety Foundation.

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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