Preference toward a polylysine enantiomer in inhibiting prions

Karen S. Jackson, Jihyun Yeom, Youngmi Han, Younsoo Bae, Chongsuk Ryou

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Differential anti-prion activity of polylysine enantiomers was studied. Based on our recent discovery that poly-l-lysine (PLK) is a potent anti-prion agent, we investigated suppression of prions in cultured cells using poly-d-lysine (PDK). The results showed that PDK was more efficacious than PLK to inhibit prions. Protein misfolding cyclic amplification assay demonstrated improved efficacy of PDK in inhibiting plasminogen-mediated prion propagation, corresponding to the enantio-preference of PDK observed in cultured cells. Furthermore, our study demonstrated that polylysines formed a complex with plasminogen. These results propose to hypothesize a plausible mechanism that elicits prion inhibition by polylysine enantiomers.

Original languageEnglish
Pages (from-to)993-1000
Number of pages8
JournalAmino Acids
Volume44
Issue number3
DOIs
StatePublished - Mar 2013

Keywords

  • Enantiomers
  • Inhibition
  • Plasminogen
  • Polylysine
  • Prion

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Preference toward a polylysine enantiomer in inhibiting prions'. Together they form a unique fingerprint.

Cite this