TY - JOUR
T1 - Prematurity, Subclinical Intraamniotic Infection, and Fetal Biophysical Parameters
T2 - Is There a Correlation?
AU - Cox, Susan M.
AU - Roberts, Scott
AU - Roussis, Percilis
AU - Campbell, Berry A.
AU - Curry, Thomas E.
PY - 1993
Y1 - 1993
N2 - Objective: This prospective study was undertaken to examine the effects of subclinical intraamniotic infection on fetal behavioral patterns. Methods: Amniotic fluid was obtained from four groups of patients (n = 99): group 1, patients with preterm premature rupture of the fetal membranes (PPROM) without infection; group 2, patients with PPROM and infection; group 3, patients with preterm labor (PTL) and without infection; and group 4, patients with PTL and infection. Fetal biophysical profiles were obtained on admission to the labor suite. Amniotic fluid was analyzed for the presence of microorganisms and endotoxin to confirm intraamniotic infection; cytokines interleukin (IL)-lß, IL-6, and IL-8 were also assayed. Results: We found no association between low scores for biophysical parameters and subclinical infection in patients with PPROM or PTL. Conclusions: We could not demonstrate that upon a patient’s admission to the labor hall absent fetal breathing and absent fetal movement, as well as reactivity, correlate with subclinical intraamniotic infection. Elevated cytokines, i.e. IL-lß, IL-6, and IL-8 were associated with subclinical chorioamnionitis.
AB - Objective: This prospective study was undertaken to examine the effects of subclinical intraamniotic infection on fetal behavioral patterns. Methods: Amniotic fluid was obtained from four groups of patients (n = 99): group 1, patients with preterm premature rupture of the fetal membranes (PPROM) without infection; group 2, patients with PPROM and infection; group 3, patients with preterm labor (PTL) and without infection; and group 4, patients with PTL and infection. Fetal biophysical profiles were obtained on admission to the labor suite. Amniotic fluid was analyzed for the presence of microorganisms and endotoxin to confirm intraamniotic infection; cytokines interleukin (IL)-lß, IL-6, and IL-8 were also assayed. Results: We found no association between low scores for biophysical parameters and subclinical infection in patients with PPROM or PTL. Conclusions: We could not demonstrate that upon a patient’s admission to the labor hall absent fetal breathing and absent fetal movement, as well as reactivity, correlate with subclinical intraamniotic infection. Elevated cytokines, i.e. IL-lß, IL-6, and IL-8 were associated with subclinical chorioamnionitis.
KW - Preterm labor, PROM, cytokines, interleukin
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U2 - 10.1155/S1064744993000183
DO - 10.1155/S1064744993000183
M3 - Article
AN - SCOPUS:6844222011
SN - 1064-7449
VL - 1
SP - 76
EP - 81
JO - Infectious Diseases in Obstetrics and Gynecology
JF - Infectious Diseases in Obstetrics and Gynecology
IS - 2
ER -