Premorbid physical activity predicts disability progression in relapsing-remitting multiple sclerosis

Robert W. Motl, Deirdre Dlugonski, Lara Pilutti, Brian Sandroff, Edward McAuley

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Background: Disability progression is a hallmark feature of multiple sclerosis (MS) that has been predicted by a variety of demographic and clinical variables and treatment with disease modifying therapies. This study examined premorbid physical activity as a predictor of change in disability over 24 months in persons with relapsing-remitting MS (RRMS). Methods: 269 persons with RRMS completed baseline measures of demographic and clinical variables, premorbid and current physical activity, and disability status. The measure of disability was further completed every six months over the subsequent 24-month period. The data were analyzed with unconditional and conditional latent growth curve modeling (LGCM). Results: The unconditional LGCM indicated that there was a significant, linear increase in disability scores over time (p =.0015). The conditional LGCM indicated that premorbid physical activity significantly predicted the linear change in disability scores (standardized β = -.23, p <.005); current physical activity (standardized β = -.02, p =.81), gender (standardized β = -.06, p =.54), age (standardized β =.05, p =.56), duration of MS (standardized β =.11, p =.15), and treatment with disease modifying therapies (standardized β = -.03, p =.77) did not predict change in disability scores. Conclusions: The current research highlights the possible role of premorbid physical activity for lessening disability progression over time in persons with RRMS. Additional research is necessary on physical activity initiated after the diagnosis of RRMS as a lifestyle approach for bolstering physiological reserve and preventing disability progression.

Original languageEnglish
Pages (from-to)123-127
Number of pages5
JournalJournal of the Neurological Sciences
Volume323
Issue number1-2
DOIs
StatePublished - Dec 15 2012

Bibliographical note

Funding Information:
Disclosures: This investigation was supported by a grant from the National Multiple Sclerosis Society ( RG 3926A2/1 ).

Funding Information:
Dr. Motl serves as a consultant for Biogen Idec and Acorda Therapeutics; has received research support from Biogen Idec and Acorda Therapeutics; and has received research support from NIH and National MS Society.

Funding Information:
Dr. Pilutti has received research support from the MS Society of Canada.

Funding Information:
Dr. McAuley has received research support from Abbot Lab, NIH, and National MS Society.

Copyright:
Copyright 2013 Elsevier B.V., All rights reserved.

Keywords

  • Disability
  • Exercise
  • Lifestyle
  • Multiple sclerosis
  • Physiological reserve

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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