This set of experiments examined the effects of prenatal buprenorphine (BUP) exposure on three measures of sexual differentiation in rats. Pregnant female rats were divided into four treatment groups: 0.6 mg/kg BUP, 0.3 mg/kg BUP, a pair-fed control (PFC), and an untreated control (UTC). Drugs were injected starting on gestation day (GD) 6 and continuing through GD 20 with a 48-h interval between drug administrations. Three variables were examined in the offspring: anogenital (AG) distance on postnatal day (PND) 1, spontaneous parental behavior on PNDs 23-28, and saccharin consumption on PNDs 42-55. Whereas prenatal BUP exposure had no effect on AG distance, spontaneous parental behavior was impaired in the 0.6-mg/kg-exposed offspring on two measures: pup-retrieval latencies and pup-directed behaviors. Furthermore, although both control groups and the 0.3-mg/kg-exposed offspring showed the expected sex difference in consumption of a 0.25% saccharin solution, this difference was not displayed by the 0.6-mg/kg-exposed offspring. These findings suggest that exposure to relatively high doses of buprenorphine during development may have long-term effects on behavior.
|Number of pages||7|
|Journal||Pharmacology Biochemistry and Behavior|
|State||Published - Oct 1997|
Bibliographical noteFunding Information:
This work was supported in part by grants from the University of Kentucky Multidisciplinary Center on Drug and Alcohol Abuse and from Psychology Department Incentive Funds to S. B. and by a Howard Hughes Undergraduate Research Award to V. M. C. Buprenorphine was obtained from the National Institute on Drug Abuse.
- Prenatal buprenorphine exposure
- Sexually dimorphic nonreproductive behaviors
ASJC Scopus subject areas
- Clinical Biochemistry
- Biological Psychiatry
- Behavioral Neuroscience