Prenatal cocaine exposure and childhood obesity at nine years

Linda L. LaGasse; Ronnesia B. Gaskins; Henrietta S. Bada; Seetha Shankaran; Jing Liu; Barry M. Lester; Charles R. Bauer; Rosemary D. Higgins; Abhik Das; Mary Roberts

doi:10.1016/j.ntt.2010.11.002

Prenatal cocaine exposure and childhood obesity at nine years

Linda L. LaGasse, Ronnesia B. Gaskins, Henrietta S. Bada, Seetha Shankaran, Jing Liu, Barry M. Lester, Charles R. Bauer, Rosemary D. Higgins, Abhik Das, Mary Roberts

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Little is known about the association between prenatal cocaine exposure and obesity. We tested whether prenatal cocaine exposure increases the likelihood of obesity in 561 9-year-old term children from the Maternal Lifestyle Study (MLS). Overall, 21.6% of children met criterion for obesity (body mass index [BMI]. ≥ 95th percentile, age and sex-specific). While there was no overall cocaine effect on obesity, multivariate logistic analysis revealed that children exposed to cocaine but not alcohol were 4 times more likely to be obese (OR 4.11, CI 2.04-9.76) than children not exposed to either drug. No increase in obesity prevalence was found in children exposed to alcohol but not cocaine (OR 1.08, CI 59-1.93) or both (OR 1.21, CI 0.66-2.22). Alcohol exposure may attenuate the effect of cocaine exposure on obesity. Increased obesity associated with cocaine but not alcohol exposure was first observed at 7. years. BMI was also elevated from 3 to 9. years in children exposed to cocaine but not alcohol, due to increasing weight but normal height. Prenatal exposure to cocaine may alter the neuroendocrine system and metabolic processes resulting in increased weight gain and childhood obesity.

Original language	English
Pages (from-to)	188-197
Number of pages	10
Journal	Neurotoxicology and Teratology
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.ntt.2010.11.002
State	Published - Mar 2011

Bibliographical note

Funding Information:
This study is part of the MLS which was conducted with support from the National Institute on Drug Abuse (NIDA) through cooperative agreements with the National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH) . Participating institutions, grant awards, investigators and key research personnel include: Warren Alpert Medical School of Brown University , U10-DA-024119 , U10-HD-27904 , N01-2-3159 (Barry M. Lester, PhD., Cynthia Miller-Loncar PhD, Linda LaGasse, PhD., and Jean Twomey, PhD); Wayne State University , U10-DA-024117 , U10-HD-21385 (Seetha Shankaran, MD, Eunice Woldt, MSN, and Jay Ann Nelson, BSN); University of Tennessee , U10-DA-024118 , U10-HD-21415 (Henrietta S. Bada, MD, Toni Whitaker, MD, Charlotte Bursi, MSSW, Leann Pollard BA and Jonathan Rowland, BS); University of Miami , U10-DA-024118 , U10-HD-21397 (Charles R. Bauer, MD, Ann L. Graziotti ARNP and Susan Gautier, MS); RTI International , U01-HD-36790 (W. Kenneth Poole, PhD, Abhik Das, PhD, Jane Hammond, PhD, Debra Fleischmann BS); National Institute on Drug Abuse (Nicolette Borek PhD and Vincent L. Smeriglio PhD); National Institute of Child Health and Human Development (Rosemary D. Higgins MD). The MLS is funded as a cooperative agreement and as such the funding sponsors (NIDA, NICHD, NIMH) have input into the design and conduct of the study.

Keywords

Childhood obesity
Fetal origins
Growth
Prenatal alcohol exposure
Prenatal cocaine exposure

ASJC Scopus subject areas

Toxicology
Developmental Neuroscience
Cellular and Molecular Neuroscience

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.ntt.2010.11.002

Cite this

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title = "Prenatal cocaine exposure and childhood obesity at nine years",

abstract = "Little is known about the association between prenatal cocaine exposure and obesity. We tested whether prenatal cocaine exposure increases the likelihood of obesity in 561 9-year-old term children from the Maternal Lifestyle Study (MLS). Overall, 21.6% of children met criterion for obesity (body mass index [BMI]. ≥ 95th percentile, age and sex-specific). While there was no overall cocaine effect on obesity, multivariate logistic analysis revealed that children exposed to cocaine but not alcohol were 4 times more likely to be obese (OR 4.11, CI 2.04-9.76) than children not exposed to either drug. No increase in obesity prevalence was found in children exposed to alcohol but not cocaine (OR 1.08, CI 59-1.93) or both (OR 1.21, CI 0.66-2.22). Alcohol exposure may attenuate the effect of cocaine exposure on obesity. Increased obesity associated with cocaine but not alcohol exposure was first observed at 7. years. BMI was also elevated from 3 to 9. years in children exposed to cocaine but not alcohol, due to increasing weight but normal height. Prenatal exposure to cocaine may alter the neuroendocrine system and metabolic processes resulting in increased weight gain and childhood obesity.",

keywords = "Childhood obesity, Fetal origins, Growth, Prenatal alcohol exposure, Prenatal cocaine exposure",

author = "LaGasse, {Linda L.} and Gaskins, {Ronnesia B.} and Bada, {Henrietta S.} and Seetha Shankaran and Jing Liu and Lester, {Barry M.} and Bauer, {Charles R.} and Higgins, {Rosemary D.} and Abhik Das and Mary Roberts",

note = "Funding Information: This study is part of the MLS which was conducted with support from the National Institute on Drug Abuse (NIDA) through cooperative agreements with the National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH) . Participating institutions, grant awards, investigators and key research personnel include: Warren Alpert Medical School of Brown University , U10-DA-024119 , U10-HD-27904 , N01-2-3159 (Barry M. Lester, PhD., Cynthia Miller-Loncar PhD, Linda LaGasse, PhD., and Jean Twomey, PhD); Wayne State University , U10-DA-024117 , U10-HD-21385 (Seetha Shankaran, MD, Eunice Woldt, MSN, and Jay Ann Nelson, BSN); University of Tennessee , U10-DA-024118 , U10-HD-21415 (Henrietta S. Bada, MD, Toni Whitaker, MD, Charlotte Bursi, MSSW, Leann Pollard BA and Jonathan Rowland, BS); University of Miami , U10-DA-024118 , U10-HD-21397 (Charles R. Bauer, MD, Ann L. Graziotti ARNP and Susan Gautier, MS); RTI International , U01-HD-36790 (W. Kenneth Poole, PhD, Abhik Das, PhD, Jane Hammond, PhD, Debra Fleischmann BS); National Institute on Drug Abuse (Nicolette Borek PhD and Vincent L. Smeriglio PhD); National Institute of Child Health and Human Development (Rosemary D. Higgins MD). The MLS is funded as a cooperative agreement and as such the funding sponsors (NIDA, NICHD, NIMH) have input into the design and conduct of the study.",

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AU - Gaskins, Ronnesia B.

AU - Bada, Henrietta S.

AU - Shankaran, Seetha

AU - Liu, Jing

AU - Lester, Barry M.

AU - Bauer, Charles R.

AU - Higgins, Rosemary D.

AU - Das, Abhik

AU - Roberts, Mary

N1 - Funding Information: This study is part of the MLS which was conducted with support from the National Institute on Drug Abuse (NIDA) through cooperative agreements with the National Institute of Child Health and Human Development (NICHD) and the National Institute of Mental Health (NIMH) . Participating institutions, grant awards, investigators and key research personnel include: Warren Alpert Medical School of Brown University , U10-DA-024119 , U10-HD-27904 , N01-2-3159 (Barry M. Lester, PhD., Cynthia Miller-Loncar PhD, Linda LaGasse, PhD., and Jean Twomey, PhD); Wayne State University , U10-DA-024117 , U10-HD-21385 (Seetha Shankaran, MD, Eunice Woldt, MSN, and Jay Ann Nelson, BSN); University of Tennessee , U10-DA-024118 , U10-HD-21415 (Henrietta S. Bada, MD, Toni Whitaker, MD, Charlotte Bursi, MSSW, Leann Pollard BA and Jonathan Rowland, BS); University of Miami , U10-DA-024118 , U10-HD-21397 (Charles R. Bauer, MD, Ann L. Graziotti ARNP and Susan Gautier, MS); RTI International , U01-HD-36790 (W. Kenneth Poole, PhD, Abhik Das, PhD, Jane Hammond, PhD, Debra Fleischmann BS); National Institute on Drug Abuse (Nicolette Borek PhD and Vincent L. Smeriglio PhD); National Institute of Child Health and Human Development (Rosemary D. Higgins MD). The MLS is funded as a cooperative agreement and as such the funding sponsors (NIDA, NICHD, NIMH) have input into the design and conduct of the study.

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KW - Growth

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Prenatal cocaine exposure and childhood obesity at nine years

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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