Prenatal cocaine exposure: Cardiorespiratory function and resilience

Stephen J. Sheinkopf, Linda L. Lagasse, Barry M. Lester, Jing Liu, Ronald Seifer, Charles R. Bauer, Seetha Shankaran, Henrietta Bada, Rosemary Higgins, Abhik Das

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

5 Scopus citations


Cardiac vagal tone (VT) was studied as a resilience factor in children prenatally exposed to cocaine and nonexposed controls (n = 550). A cumulative risk index was derived and used to classify children as high versus low risk. VT was measured during mildly stressful observations at 1 and 36 months of age. Children were classified as having consistently high, consistently low, or fluctuating VT. Risk and VT interacted to predict adaptive behaviors. For high-risk children, low VT was related to higher ratings of adaptive behaviors. This finding suggests that regulatory functioning, as indexed by VT, may be a protective factor in prenatal CE.

Original languageEnglish
Title of host publicationResilience in Children
Number of pages5
StatePublished - Dec 2006

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Children
  • Cocaine
  • Cumulative risk
  • Developmental outcome
  • Heart rate variability
  • Prenatal drug exposure
  • Vagal tone

ASJC Scopus subject areas

  • Neuroscience (all)
  • Biochemistry, Genetics and Molecular Biology (all)
  • History and Philosophy of Science


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