Prenatal cocaine exposure: Cardiorespiratory function and resilience

Stephen J. Sheinkopf; Linda L. Lagasse; Barry M. Lester; Jing Liu; Ronald Seifer; Charles R. Bauer; Seetha Shankaran; Henrietta Bada; Rosemary Higgins; Abhik Das

doi:10.1196/annals.1376.049

Prenatal cocaine exposure: Cardiorespiratory function and resilience

Stephen J. Sheinkopf, Linda L. Lagasse, Barry M. Lester, Jing Liu, Ronald Seifer, Charles R. Bauer, Seetha Shankaran, Henrietta Bada, Rosemary Higgins, Abhik Das

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

5 Scopus citations

Abstract

Cardiac vagal tone (VT) was studied as a resilience factor in children prenatally exposed to cocaine and nonexposed controls (n = 550). A cumulative risk index was derived and used to classify children as high versus low risk. VT was measured during mildly stressful observations at 1 and 36 months of age. Children were classified as having consistently high, consistently low, or fluctuating VT. Risk and VT interacted to predict adaptive behaviors. For high-risk children, low VT was related to higher ratings of adaptive behaviors. This finding suggests that regulatory functioning, as indexed by VT, may be a protective factor in prenatal CE.

Original language	English
Title of host publication	Resilience in Children
Pages	354-358
Number of pages	5
DOIs	https://doi.org/10.1196/annals.1376.049
State	Published - Dec 2006

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1094
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Funding

Funders

Funder number

Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse

U10DA024119

Author National Institute on Drug Abuse DA031791 Mark J Ferris National Institute on Drug Abuse DA006634 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA026117 Mark J Ferris National Institute on Alcohol Abuse and Alcoholism AA028162 Elizabeth G Pitts National Institute of General Medical Sciences GM102773 Elizabeth G Pitts Peter McManus Charitable Trust Mark J Ferris National Institute on Drug Abuse

Keywords

Children
Cocaine
Cumulative risk
Developmental outcome
Heart rate variability
Prenatal drug exposure
Vagal tone

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
History and Philosophy of Science

Access to Document

10.1196/annals.1376.049

Cite this

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title = "Prenatal cocaine exposure: Cardiorespiratory function and resilience",

abstract = "Cardiac vagal tone (VT) was studied as a resilience factor in children prenatally exposed to cocaine and nonexposed controls (n = 550). A cumulative risk index was derived and used to classify children as high versus low risk. VT was measured during mildly stressful observations at 1 and 36 months of age. Children were classified as having consistently high, consistently low, or fluctuating VT. Risk and VT interacted to predict adaptive behaviors. For high-risk children, low VT was related to higher ratings of adaptive behaviors. This finding suggests that regulatory functioning, as indexed by VT, may be a protective factor in prenatal CE.",

keywords = "Children, Cocaine, Cumulative risk, Developmental outcome, Heart rate variability, Prenatal drug exposure, Vagal tone",

author = "Sheinkopf, \{Stephen J.\} and Lagasse, \{Linda L.\} and Lester, \{Barry M.\} and Jing Liu and Ronald Seifer and Bauer, \{Charles R.\} and Seetha Shankaran and Henrietta Bada and Rosemary Higgins and Abhik Das",

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doi = "10.1196/annals.1376.049",

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T2 - Cardiorespiratory function and resilience

AU - Sheinkopf, Stephen J.

AU - Lagasse, Linda L.

AU - Lester, Barry M.

AU - Liu, Jing

AU - Seifer, Ronald

AU - Bauer, Charles R.

AU - Shankaran, Seetha

AU - Bada, Henrietta

AU - Higgins, Rosemary

AU - Das, Abhik

PY - 2006/12

Y1 - 2006/12

N2 - Cardiac vagal tone (VT) was studied as a resilience factor in children prenatally exposed to cocaine and nonexposed controls (n = 550). A cumulative risk index was derived and used to classify children as high versus low risk. VT was measured during mildly stressful observations at 1 and 36 months of age. Children were classified as having consistently high, consistently low, or fluctuating VT. Risk and VT interacted to predict adaptive behaviors. For high-risk children, low VT was related to higher ratings of adaptive behaviors. This finding suggests that regulatory functioning, as indexed by VT, may be a protective factor in prenatal CE.

AB - Cardiac vagal tone (VT) was studied as a resilience factor in children prenatally exposed to cocaine and nonexposed controls (n = 550). A cumulative risk index was derived and used to classify children as high versus low risk. VT was measured during mildly stressful observations at 1 and 36 months of age. Children were classified as having consistently high, consistently low, or fluctuating VT. Risk and VT interacted to predict adaptive behaviors. For high-risk children, low VT was related to higher ratings of adaptive behaviors. This finding suggests that regulatory functioning, as indexed by VT, may be a protective factor in prenatal CE.

KW - Children

KW - Cocaine

KW - Cumulative risk

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KW - Heart rate variability

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KW - Vagal tone

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Prenatal cocaine exposure: Cardiorespiratory function and resilience

Abstract

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Keywords

ASJC Scopus subject areas

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