TY - JOUR
T1 - Prenatal nicotine alters vigilance states and AchR gene expression in the neonatal rat
T2 - Implications for SIDS
AU - Frank, Marcos G.
AU - Srere, Hilary
AU - Ledezma, Carlos
AU - O'Hara, Bruce
AU - Heller, H. Craig
PY - 2001
Y1 - 2001
N2 - Maternal smoking is a major risk factor for sudden infant death syndrome (SIDS). The mechanisms by which cigarette smoke predisposes infants to SIDS are not known. We examined the effects of prenatal nicotine exposure on sleep/wake ontogenesis and central cholinergic receptor gene expression in the neonatal rat. Prenatal nicotine exposure transiently increased sleep continuity and accelerated sleep/wake ontogeny in the neonatal rat. Prenatal nicotine also upregulated nicotinic and muscarinic cholinergic receptor mRNAs in brain regions involved in regulating vigilance states. These findings suggest that the nicotine contained in cigarette smoke may predispose human infants to SIDS by interfering with the normal maturation of sleep and wake.
AB - Maternal smoking is a major risk factor for sudden infant death syndrome (SIDS). The mechanisms by which cigarette smoke predisposes infants to SIDS are not known. We examined the effects of prenatal nicotine exposure on sleep/wake ontogenesis and central cholinergic receptor gene expression in the neonatal rat. Prenatal nicotine exposure transiently increased sleep continuity and accelerated sleep/wake ontogeny in the neonatal rat. Prenatal nicotine also upregulated nicotinic and muscarinic cholinergic receptor mRNAs in brain regions involved in regulating vigilance states. These findings suggest that the nicotine contained in cigarette smoke may predispose human infants to SIDS by interfering with the normal maturation of sleep and wake.
KW - Cholinergic receptors
KW - Sleep
KW - Smoking
KW - Sudden infant death syndrome
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U2 - 10.1152/ajpregu.2001.280.4.r1134
DO - 10.1152/ajpregu.2001.280.4.r1134
M3 - Article
C2 - 11247836
AN - SCOPUS:0035006409
SN - 0363-6119
VL - 280
SP - R1134-R1140
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 4 49-4
ER -