Objective: The purpose of this study was to determine if patients receiving statin therapy before coronary artery bypass grafting surgery would have less cognitive dysfunction after cardiopulmonary bypass as a consequence of a diminished inflammatory response. Design: Retrospective observational study of patients undergoing coronary artery bypass grafting surgery. Setting: Referral center for cardiothoracic surgery at a university hospital. Participants: Four hundred forty patients undergoing coronary artery bypass grafting surgery with cardiopulmonary bypass. Interventions: None. Measurements and Main Results: Thirty-five percent of patients received statins in the preoperative period. Multivariable analysis revealed no effect of preoperative statin therapy on cognitive function (p = 0.67). Post hoc analysis revealed that statin therapy at hospital discharge was associated with less improvement in cognitive performance at 6 weeks after surgery (p = 0.011). No significant differences were found between statin therapy groups in either range or maximum value of any of the cytokines (p > 0.05). Conclusions: Preoperative statin therapy did not decrease the inflammatory response to cardiopulmonary bypass or the cognitive dysfunction commonly seen after cardiac surgery.
|Number of pages||6|
|Journal||Journal of Cardiothoracic and Vascular Anesthesia|
|State||Published - Jun 2005|
Bibliographical noteFunding Information:
Supported in part by NIH RO1-AG09663-4; NIH RO1-HL54316; National Center for Research Resources, Clinical Research Centers Program, NIH MO1-RR-30.
- C-reactive protein
- Cardiopulmonary bypass
- Coronary artery bypass
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Anesthesiology and Pain Medicine