Preparation and characterization of multimodal hybrid organic and inorganic nanocrystals of camptothecin and gold

Christin P. Hollis, Alan K. Dozier, Barbara L. Knutson, Tonglei Li

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We demonstrate a novel inorganic-organic crystalline nanoconstruct, where gold atoms were imbedded in the crystal lattices as defects of camptothecin nanocrystals, suggesting its potential use as simultaneous agents for cancer therapy and bioimaging. The incorporation of gold, a potential computed tomography (CT) contrast agent, in the nanocrystals of camptothecin was detected by transmission electron microscope (TEM) and further quantified by energy dispersive X-ray spectrometry (EDS) and inductively coupled plasma-optical emission spectrometers (ICP-OES). Due to gold's high attenuation coefficient, only a relatively small amount needs to be present in order to create a good noise-to-contrast ratio in CT imaging. The imbedded gold atoms and clusters are expected to share the same biological fate as the camptothecin nanocrystals, reaching and accumulating in tumor site due to the enhanced permeation and retention (EPR) effect.

Original languageEnglish
Pages (from-to)128-134
Number of pages7
JournalActa Pharmaceutica Sinica B
Volume9
Issue number1
DOIs
StatePublished - Jan 2019

Bibliographical note

Publisher Copyright:
© 2019 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences

Keywords

  • Camptothecin
  • Cancer therapy and diagnosis
  • Computed tomography (CT) contrast agent
  • Drug delivery
  • Gold nanoparticles
  • Hybrid inorganic-organic

ASJC Scopus subject areas

  • General Pharmacology, Toxicology and Pharmaceutics

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