TY - JOUR
T1 - Presence of epstein-barr virus in many types of benign and malignant lymphoid lesions
T2 - Detection by polymerase chain reaction and in situ hybridization
AU - Hardarson, Sverrir
AU - Anderson, Mary E.
AU - Lutz, Charles T.
PY - 1994/3
Y1 - 1994/3
N2 - Epstein-Barr virus (EBV) has been detected in African Burkitt's lymphoma, posttransplant lymphoproliferative disease, and a variable fraction of Hodgkin's lymphomas. To assess if EBV is associated with other lymphoid proliferations, we evaluated a wide variety of benign and malignant lymphoid lesions, using polymerase chain reaction and a sensitive in situ hybridization method. Abundant EBV +cells were seen in posttransplant lymphomas, some B cell immunoblastic lymphomas, and in tonsils from patients with infectious mononucleosis. Intermediate numbers of EBV +cells were seen in a mixed B cell lymphoma, peripheral T cell lymphomas, and in syncytial variants of Hodgkin's disease as well as a lymph node from a patient with infectious mononucleosis. Low numbers of EBV +cells were detected in normal and reactive lymph nodes, B and T cell lymphomas, and Hodgkin's lymphomas. The variable extent of EBV infection in lymphoid lesions suggests that EBV may play a variety of roles in the development of malignant and nonmalignant lymphoid lesions.
AB - Epstein-Barr virus (EBV) has been detected in African Burkitt's lymphoma, posttransplant lymphoproliferative disease, and a variable fraction of Hodgkin's lymphomas. To assess if EBV is associated with other lymphoid proliferations, we evaluated a wide variety of benign and malignant lymphoid lesions, using polymerase chain reaction and a sensitive in situ hybridization method. Abundant EBV +cells were seen in posttransplant lymphomas, some B cell immunoblastic lymphomas, and in tonsils from patients with infectious mononucleosis. Intermediate numbers of EBV +cells were seen in a mixed B cell lymphoma, peripheral T cell lymphomas, and in syncytial variants of Hodgkin's disease as well as a lymph node from a patient with infectious mononucleosis. Low numbers of EBV +cells were detected in normal and reactive lymph nodes, B and T cell lymphomas, and Hodgkin's lymphomas. The variable extent of EBV infection in lymphoid lesions suggests that EBV may play a variety of roles in the development of malignant and nonmalignant lymphoid lesions.
KW - Barr virus
KW - Epstein
KW - Hodgkin’s disease
KW - In situ hybridization
KW - Lymphoma
KW - Polymerase chain reaction
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U2 - 10.1097/00019606-199403010-00005
DO - 10.1097/00019606-199403010-00005
M3 - Article
C2 - 8162252
AN - SCOPUS:0028031913
SN - 1052-9551
VL - 3
SP - 22
EP - 31
JO - Diagnostic Molecular Pathology
JF - Diagnostic Molecular Pathology
IS - 1
ER -