Presence of high concentrations of circulating Toxoplasma antigens during acute Toxoplasma infection in athymic nude mice

Y. Suzuki, A. Kobayashi

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In mice infected with an avirulent strain of Toxoplasma gondii, circulatinig Toxoplasma antigens were detectable in the sera during weeks 1 to 3 of infection by a simple agglutination test that uses latex particles coated with anti-Toxoplasma antibodies. An infection in athymic nude mice resulted in high agglutination titers in the anti-Toxoplasma antibody-coated latex particle test and the absence of anti-Toxoplasma antibodies in sera during the acute phase, suggesting that the detection of circulating Toxoplasma antigens is a good tool for the diagnosis of acute toxoplasmosis, especially in severely immunocompromised hosts.

Original languageEnglish
Pages (from-to)1017-1018
Number of pages2
JournalInfection and Immunity
Volume55
Issue number4
StatePublished - 1987

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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