Prestin up-regulation in chronic salicylate (aspirin) administration: An implication of functional dependence of prestin expression

N. Yu, M. L. Zhu, B. Johnson, Y. P. Liu, R. O. Jones, H. B. Zhao

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Salicylate (aspirin) can reversibly eliminate outer hair cell (OHC) electromotility to induce hearing loss. Prestin is the OHC electromotility motor protein. Here we report that, consistence with increase in distortion product otoacoustic emission, long-term administration of salicylate can increase prestin expression and OHC electromotility. The prestin expression at the mRNA and protein levels was increased by three- to four-fold. In contrast to the acute inhibition, the OHC electromotility associated charge density was also increased by 18%. This incremental increase was reversible. After cessation of salicylate administration, the prestin expression returned to normal. We also found that long-term administration of salicylate did not alter cyclooxygenase (Cox) II expression but down-regulated NF-κB and increased nuclear transcription factors c-fos and egr-1. The data suggest that prestin expression in vivo is dynamically up-regulated to increase OHC electromotility in long-term administration of salicylate via the Cox-II-independent pathways.

Original languageEnglish
Pages (from-to)2407-2418
Number of pages12
JournalCellular and Molecular Life Sciences
Volume65
Issue number15
DOIs
StatePublished - Aug 2008

Keywords

  • Aspirin
  • Functional dependence
  • Hearing
  • Outer hair cell electromotility
  • Prestin
  • Salicylate
  • Tinnitus

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

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