Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice

Liu Li; Jiong Ding; Charles Marshall; Junying Gao; Gang Hu; Ming Xiao

doi:10.1016/j.bbr.2010.10.032

Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice

Liu Li, Jiong Ding, Charles Marshall, Junying Gao, Gang Hu, Ming Xiao

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.

Original language	English
Pages (from-to)	244-247
Number of pages	4
Journal	Behavioural Brain Research
Volume	217
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2010.10.032
State	Published - Feb 2 2011

Bibliographical note

Funding Information:
This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).

Keywords

Alzheimer's disease
D-galactose
Mice
Morris water maze
Spatial learning and memory

ASJC Scopus subject areas

Behavioral Neuroscience

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10.1016/j.bbr.2010.10.032

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title = "Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice",

abstract = "There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.",

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author = "Liu Li and Jiong Ding and Charles Marshall and Junying Gao and Gang Hu and Ming Xiao",

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AU - Ding, Jiong

AU - Marshall, Charles

AU - Gao, Junying

AU - Hu, Gang

AU - Xiao, Ming

N1 - Funding Information: This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).

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KW - Spatial learning and memory

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Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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