Pretraining affects Morris water maze performance with different patterns between control and ovariectomized plus d-galactose-injected mice

Liu Li, Jiong Ding, Charles Marshall, Junying Gao, Gang Hu, Ming Xiao

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.

Original languageEnglish
Pages (from-to)244-247
Number of pages4
JournalBehavioural Brain Research
Volume217
Issue number1
DOIs
StatePublished - Feb 2 2011

Bibliographical note

Funding Information:
This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).

Keywords

  • Alzheimer's disease
  • D-galactose
  • Mice
  • Morris water maze
  • Spatial learning and memory

ASJC Scopus subject areas

  • Behavioral Neuroscience

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