There is little literature addressing the influences of the repeated Morris water maze (MWM) test on behavioral performance under physiological and neurodegenerative conditions. The results revealed that pretraining had distinctively different effects on MWM performances of vehicle control mice and Alzheimer's disease model mice induced by ovariectomy plus injection of d-galactose after an 8-w interval. This interference effect should be considered during analyzing behavioral outcomes using repeated MWM tests.
|Number of pages||4|
|Journal||Behavioural Brain Research|
|State||Published - Feb 2 2011|
Bibliographical noteFunding Information:
This work was supported by the grants from National Natural Science Foundation of China (Nos. 30971020 and 30973517 ) and Natural Science Foundation of Jiangsu Educational Department ( 09KJA310003 ).
- Alzheimer's disease
- Morris water maze
- Spatial learning and memory
ASJC Scopus subject areas
- Behavioral Neuroscience