TY - JOUR
T1 - Prevalence and characterization of seven-segmented influenza viruses in bovine respiratory disease complex
AU - Uprety, Tirth
AU - Sreenivasan, Chithra C.
AU - Thomas, Milton
AU - Hause, Ben
AU - Christopher-Hennings, Jane
AU - Miskimis, Dale
AU - Pillatzki, Angela
AU - Nelson, Eric
AU - Wang, Dan
AU - Feng, Li
N1 - Publisher Copyright:
© 2023 Elsevier Inc.
PY - 2023/10
Y1 - 2023/10
N2 - Bovine respiratory disease (BRD) complex is a multifactorial respiratory disease of cattle. Seven-segmented influenza C (ICV) and D (IDV) viruses have been identified in cattle with BRD, however, molecular epidemiology and prevalence of IDV and ICV in the diseased population remain poorly characterized. Here, we conducted a molecular screening of 208 lung samples of bovine pneumonia cases for the presence of IDV and ICV. Our results demonstrated that both viruses were prevalent in BRD cases and the overall positivity rates of IDV and ICV were 20.88% and 5.99% respectively. Further analysis of three IDV strains isolated from lungs of cattle with BRD showed that these lung-tropic strains belonged to D/Michigan/2019 clade and diverged antigenically from the circulating dominant IDV clades D/OK and D/660. Our results reveal that IDV and ICV are associated with BRD complex and support a role for IDV and ICV in the etiology of BRD.
AB - Bovine respiratory disease (BRD) complex is a multifactorial respiratory disease of cattle. Seven-segmented influenza C (ICV) and D (IDV) viruses have been identified in cattle with BRD, however, molecular epidemiology and prevalence of IDV and ICV in the diseased population remain poorly characterized. Here, we conducted a molecular screening of 208 lung samples of bovine pneumonia cases for the presence of IDV and ICV. Our results demonstrated that both viruses were prevalent in BRD cases and the overall positivity rates of IDV and ICV were 20.88% and 5.99% respectively. Further analysis of three IDV strains isolated from lungs of cattle with BRD showed that these lung-tropic strains belonged to D/Michigan/2019 clade and diverged antigenically from the circulating dominant IDV clades D/OK and D/660. Our results reveal that IDV and ICV are associated with BRD complex and support a role for IDV and ICV in the etiology of BRD.
KW - Bovine respiratory disease
KW - Cattle
KW - Influenza C virus
KW - Influenza D virus
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U2 - 10.1016/j.virol.2023.109859
DO - 10.1016/j.virol.2023.109859
M3 - Article
C2 - 37544044
AN - SCOPUS:85166987524
SN - 0042-6822
VL - 587
JO - Virology
JF - Virology
M1 - 109859
ER -