Prevalence of mathematical and visuospatial learning disabilities in patients with posterior cortical atrophy

Zachary A. Miller, Lynne Rosenberg, Miguel A. Santos-Santos, Melanie Stephens, Isabel E. Allen, H. Isabel Hubbard, Averill Cantwell, Maria Luisa Mandelli, Lea T. Grinberg, William W. Seeley, Bruce L. Miller, Gil D. Rabinovici, Maria Luisa Gorno-Tempini

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42 Scopus citations

Abstract

IMPORTANCE Increased prevalence of language-based learning disabilities (LDs) has been previously reported in patients with primary progressive aphasia (PPA). This study hypothesized that patients with focal neurodegenerative syndromes outside the language network, such as posterior cortical atrophy (PCA), would have a higher rate of nonlanguage LDs, congruent with their mainly visuospatial presentation. OBJECTIVE To investigate the prevalence and type of LD (language and/or mathematical and visuospatial) in a large cohort of patients with PCA compared with patients with logopenic variant PPA (lvPPA) and amnestic Alzheimer disease (AD). DESIGN, SETTING, AND PARTICIPANTS This case-control study reviewed 279 medical records from a university-based clinic and research center for patients with neurodegenerative diseases for LD history, including patients with PCA (n = 95), patients with lvPPA (n = 84), and a matched cohort with amnestic AD (n = 100). No records were excluded. The study compared cognitive and neuroimaging features of patients with PCA with and without LDs. A review of the records of patients presenting from March 1, 1999, to August 31, 2014, revealed 95 PCA cases and 84 lvPPA cases. Then 100 patients with amnestic AD from this same period were chosen for comparison, matching against the groups for age, sex, and disease severity. Data analysis was performed from September 8, 2013, to November 6, 2017. MAIN OUTCOMES AND MEASURES Prevalence of total LD history and prevalence of language and mathematical or visuospatial LD history across all cohorts. RESULTS A total of 179 atypical AD cases (95 with PCA and 84 with lvPPA) and 100 disease control cases (amnestic AD)were included in the study. The groupswere not statistically different for mean (SD) age at first visit (PCA, 61.9 [7.0] years; lvPPA, 65.1 [8.7] years; amnestic AD, 64.0 [12.6] years; P = .08), mean (SD) age at first symptom (PCA, 57.5 [7.0] years; lvPPA, 61.1 [9.0] years; amnestic AD, 59.6 [13.7] years; P = .06), or sex (PCA, 66.3%female; lvPPA, 56.0%female; amnestic AD, 57.0%female; P = .30) but differed on non-right-hand preference (PCA, 18.3%; lvPPA, 20.2%; amnestic AD, 7.7%; P = .04), race/ethnicity (PCA, 88.3%white; lvPPA, 99.0%white; amnestic AD, 80.0%white; P < .001), and mean (SD) educational level (PCA, 15.7 [3.2] years; lvPPA, 16.2 [3.3] years; amnestic AD, 14.8 [3.5] years; P = .02). A total of 18 of the 95 patients with PCA (18.9%) reported a history of LD, which is greater than the 3 of 100 patients (3.0%) in the amnestic AD cohort (P < .001) and the 10.0%expected rate in the general population (P = .007). In the PCA cohort, 13 of 95 patients (13.7%) had a nonlanguage mathematical and/or visuospatial LD; this ratewas greater than that in the amnestic AD (1 of 100 [1.0%]; P < .001) and lvPPA (2 of 84 [2.4%]; P = .006) cohorts and greater than the 6.0% expected general population rate of mathematical LD (P = .003). Compared with the patients with PCA without LDs, the group with LDs had greater preservation of global cognition and a more right-lateralized pattern of atrophy. CONCLUSIONS AND RELEVANCE Nonlanguage mathematical and visuospatial LDswere associated with focal, visuospatial predominant neurodegenerative clinical syndromes. This finding supports the hypothesis that neurodevelopmental differences in specific brain networks are associated with phenotypic manifestation of later-life neurodegenerative disease.

Original languageEnglish
Pages (from-to)728-737
Number of pages10
JournalJAMA Neurology
Volume75
Issue number6
DOIs
StatePublished - Jun 2018

Bibliographical note

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© 2018 American Medical Association. All rights reserved.

ASJC Scopus subject areas

  • Clinical Neurology

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