Introduction: Brain tumor treatment and survival information is generally limited in large-scale cancer datasets. We provide a clinical investigation of current patterns of care and survival estimates for central nervous system (CNS) tumors treated in the United States. Methods: We analyzed the National Cancer Database from 2004–2015 for all patients with diagnosis of primary CNS tumors. We describe patient demographics, treatment modality, and analyzed survival estimates. Results: 512,168 patient tumor records were examined. The most common histology was meningioma (43.6%), followed by glioblastoma (22.0%), and nerve sheath tumors (10.6%). Patients had a median age of 60 years, with a female (57.9%), white (85.0%), and non-Hispanic (87.8%) predominance. Tumors were reported as World Health Organization (WHO) grade I for 55.9% of the patients, grade II for 5.9%, grade III for 4.4%, grade IV for 24.3%, and grade unknown or not applicable for 9.4%. Overall, 56% underwent surgical procedures, 30.4% received radiation, and 20.6% received chemotherapy. Radiation plus chemotherapy and surgery was the most common treatment modality in high-grade tumors (40.5% in WHO grade III and 49.3% in WHO grade IV), while surgery only or watchful waiting was preferred in low-grade tumors. Older age, male gender, non-Hispanic origin, higher number of comorbidities, and lower socioeconomic status were identified as risk factors for mortality. Conclusions: Our analysis provides long-term survival estimates and initial treatment decisions for patients with CNS tumors in hospitals throughout the United States. Age, comorbidities, gender, ethnicity, and socioeconomic characteristics were determinants of survival.
|Number of pages||13|
|Journal||Journal of Neuro-Oncology|
|State||Published - Aug 15 2019|
Bibliographical noteFunding Information:
Funding Supported by the Biostatistics and Bioinformatics Shared Resource of the University of Kentucky Markey Cancer Center (P30CA177558).
NCDB is a hospital-based dataset comprising data from over 1500 hospital cancer centers. It is supported by the American College of Surgeons Commission on Cancer (CoC) and the American Cancer Society, under well-established quality standards on collection methods [10, 11]. This database provides a unique opportunity to assess patterns of care with high-quality treatment information and survival estimates in a hospital-based setting, providing valuable information for primary CNS tumors . A list of the CoC centers in the United States is available on the American College of Surgeons website (https://www.facs.org/search/cancer-progr ams) .
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
- Primary CNS tumors
ASJC Scopus subject areas
- Clinical Neurology
- Cancer Research