Principles in the management of pediatric intestinal leiomyosarcomas

Patrick C. McGrath, James P. Neifeld, Saul Kay, Arnold M. Salzberg

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Primary intestinal leiomyosarcomas in children are unusual tumors with little known about their natural history. Two patients (aged 9 and 10 years) with leiomyosarcoma of the jejunum treated at our institution are reported and added to the 20 other patients reported in the literature. The first patient had a grade 1 leiomyosarcoma completely resected, received no additional therapy, and remains alive with no evidence of disease 14 years later. The second patient presented with a perforated grade 2 leiomyosarcoma which was incompletely resected; he received combination chemotherapy with an initial good response, but eventually died from sarcomatosis 7 years after initial diagnosis. The 22 cases of pediatric intestinal leiomyosarcoma presented more commonly with obstruction or perforation, were able to be completely resected more often, and appear to have a better prognosis than in adults. Thus, intestinal leiomyosarcomas in children appear to have a natural history different from that of the same tumor arising in adults.

Original languageEnglish
Pages (from-to)939-941
Number of pages3
JournalJournal of Pediatric Surgery
Issue number10
StatePublished - Oct 1988


  • intestinal tumors in childhood
  • Leiomyosarcoma

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health


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