PRL-3 promotes a positive feedback loop between STAT1/2-induced gene expression and glycolysis in multiple myeloma

Caroline N. Smith, Jessica S. Blackburn

Research output: Contribution to journalComment/debate

1 Scopus citations

Abstract

Over 34 000 patients are diagnosed yearly with multiple myeloma (MM), which remains a fatal malignancy. Expression of the phosphatase PRL-3 is associated with poor prognosis in MM patients, and Vandsemb et al. have demonstrated that PRL-3 contributes to enhanced MM cell fitness through activation of a glycolysis-associated feedback loop. PRL-3 resulted in increased expression of signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) and increased glycolysis. Increased glucose metabolism in turn activated STAT1/2 and interferon 1-related genes. This discovery advances the MM field by providing a new potential treatment avenue. Comment on: https://doi.org/10.1111/febs.16058.

Original languageEnglish
Pages (from-to)6674-6676
Number of pages3
JournalFEBS Journal
Volume288
Issue number23
DOIs
StatePublished - Dec 2021

Bibliographical note

Funding Information:
CNS and JSB are supported by funding from the National Cancer Institute, R37CA227656. Figures in this manuscript were created with BioRender.com .

Publisher Copyright:
© 2021 Federation of European Biochemical Societies.

Keywords

  • IFN-1
  • IL-6
  • PTP4A3
  • glucose
  • interferon-stimulated genes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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