Over 34 000 patients are diagnosed yearly with multiple myeloma (MM), which remains a fatal malignancy. Expression of the phosphatase PRL-3 is associated with poor prognosis in MM patients, and Vandsemb et al. have demonstrated that PRL-3 contributes to enhanced MM cell fitness through activation of a glycolysis-associated feedback loop. PRL-3 resulted in increased expression of signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) and increased glycolysis. Increased glucose metabolism in turn activated STAT1/2 and interferon 1-related genes. This discovery advances the MM field by providing a new potential treatment avenue. Comment on: https://doi.org/10.1111/febs.16058.
Bibliographical noteFunding Information:
CNS and JSB are supported by funding from the National Cancer Institute, R37CA227656. Figures in this manuscript were created with BioRender.com .
© 2021 Federation of European Biochemical Societies.
- interferon-stimulated genes
ASJC Scopus subject areas
- Molecular Biology
- Cell Biology