PRL-3 promotes a positive feedback loop between STAT1/2-induced gene expression and glycolysis in multiple myeloma

Caroline N. Smith; Jessica S. Blackburn

doi:10.1111/febs.16120

PRL-3 promotes a positive feedback loop between STAT1/2-induced gene expression and glycolysis in multiple myeloma

Caroline N. Smith
, Jessica S. Blackburn

Research output: Contribution to journal › Comment/debate

6 Scopus citations

Abstract

Over 34 000 patients are diagnosed yearly with multiple myeloma (MM), which remains a fatal malignancy. Expression of the phosphatase PRL-3 is associated with poor prognosis in MM patients, and Vandsemb et al. have demonstrated that PRL-3 contributes to enhanced MM cell fitness through activation of a glycolysis-associated feedback loop. PRL-3 resulted in increased expression of signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) and increased glycolysis. Increased glucose metabolism in turn activated STAT1/2 and interferon 1-related genes. This discovery advances the MM field by providing a new potential treatment avenue. Comment on: https://doi.org/10.1111/febs.16058.

Original language	English
Pages (from-to)	6674-6676
Number of pages	3
Journal	FEBS Journal
Volume	288
Issue number	23
DOIs	https://doi.org/10.1111/febs.16120
State	Published - Dec 2021

Bibliographical note

Publisher Copyright:
© 2021 Federation of European Biochemical Societies.

Funding

CNS and JSB are supported by funding from the National Cancer Institute, R37CA227656. Figures in this manuscript were created with BioRender.com .

Funders	Funder number
National Childhood Cancer Registry – National Cancer Institute	R37CA227656

Keywords

IFN-1
IL-6
PTP4A3
glucose
interferon-stimulated genes

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Cell Biology

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10.1111/febs.16120

Cite this

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title = "PRL-3 promotes a positive feedback loop between STAT1/2-induced gene expression and glycolysis in multiple myeloma",

abstract = "Over 34 000 patients are diagnosed yearly with multiple myeloma (MM), which remains a fatal malignancy. Expression of the phosphatase PRL-3 is associated with poor prognosis in MM patients, and Vandsemb et al. have demonstrated that PRL-3 contributes to enhanced MM cell fitness through activation of a glycolysis-associated feedback loop. PRL-3 resulted in increased expression of signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) and increased glycolysis. Increased glucose metabolism in turn activated STAT1/2 and interferon 1-related genes. This discovery advances the MM field by providing a new potential treatment avenue. Comment on: https://doi.org/10.1111/febs.16058.",

keywords = "IFN-1, IL-6, PTP4A3, glucose, interferon-stimulated genes",

author = "Smith, \{Caroline N.\} and Blackburn, \{Jessica S.\}",

note = "Publisher Copyright: {\textcopyright} 2021 Federation of European Biochemical Societies.",

year = "2021",

month = dec,

doi = "10.1111/febs.16120",

language = "English",

volume = "288",

pages = "6674--6676",

number = "23",

}

TY - JOUR

T1 - PRL-3 promotes a positive feedback loop between STAT1/2-induced gene expression and glycolysis in multiple myeloma

AU - Smith, Caroline N.

AU - Blackburn, Jessica S.

PY - 2021/12

Y1 - 2021/12

N2 - Over 34 000 patients are diagnosed yearly with multiple myeloma (MM), which remains a fatal malignancy. Expression of the phosphatase PRL-3 is associated with poor prognosis in MM patients, and Vandsemb et al. have demonstrated that PRL-3 contributes to enhanced MM cell fitness through activation of a glycolysis-associated feedback loop. PRL-3 resulted in increased expression of signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) and increased glycolysis. Increased glucose metabolism in turn activated STAT1/2 and interferon 1-related genes. This discovery advances the MM field by providing a new potential treatment avenue. Comment on: https://doi.org/10.1111/febs.16058.

AB - Over 34 000 patients are diagnosed yearly with multiple myeloma (MM), which remains a fatal malignancy. Expression of the phosphatase PRL-3 is associated with poor prognosis in MM patients, and Vandsemb et al. have demonstrated that PRL-3 contributes to enhanced MM cell fitness through activation of a glycolysis-associated feedback loop. PRL-3 resulted in increased expression of signal transducer and activator of transcription 1 (STAT1) and 2 (STAT2) and increased glycolysis. Increased glucose metabolism in turn activated STAT1/2 and interferon 1-related genes. This discovery advances the MM field by providing a new potential treatment avenue. Comment on: https://doi.org/10.1111/febs.16058.

KW - IFN-1

KW - IL-6

KW - PTP4A3

KW - glucose

KW - interferon-stimulated genes

UR - https://www.scopus.com/pages/publications/85111485874

UR - https://www.scopus.com/pages/publications/85111485874#tab=citedBy

U2 - 10.1111/febs.16120

DO - 10.1111/febs.16120

M3 - Comment/debate

C2 - 34327809

AN - SCOPUS:85111485874

SN - 1742-464X

VL - 288

SP - 6674

EP - 6676

JO - FEBS Journal

JF - FEBS Journal

IS - 23

ER -

PRL-3 promotes a positive feedback loop between STAT1/2-induced gene expression and glycolysis in multiple myeloma

Abstract

Bibliographical note

Funding

Keywords

ASJC Scopus subject areas

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