Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons

Thomas A. Pitler, Philip W. Landfield

Research output: Contribution to journalArticlepeer-review

23 Scopus citations

Abstract

In rat hippocampal neurons, current- and single-electrode voltage-clamp analyses revealed a pronounced inactivation of probable Ca2+ currents (ICa), which was dependent on the amount of Ca2+ influx. Studies were conducted in cesium-loaded, tetrodotoxin-treated brain slice neurons in which known contaminating currents were blocked. These results therefore provide the first clear evidence that apparent Ca2+-mediated inactivation of ICa is an important mechanism with which mammalian brain neurons limit Ca2+ influx.

Original languageEnglish
Pages (from-to)147-153
Number of pages7
JournalBrain Research
Volume410
Issue number1
DOIs
StatePublished - Apr 28 1987

Bibliographical note

Funding Information:
This research was supported in part by Grants AG 04542 and AG 04207 from the NIH. We appreciate the excellent technical assistance of D.S. Kerr and the valuable clerical assistance of D. Lefler.

Keywords

  • Ca current
  • Ca spike
  • Conductance
  • Hippocampus
  • Inactivation
  • Vertebrate central nervous system
  • Voltage-clamp

ASJC Scopus subject areas

  • Neuroscience (all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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