In rat hippocampal neurons, current- and single-electrode voltage-clamp analyses revealed a pronounced inactivation of probable Ca2+ currents (ICa), which was dependent on the amount of Ca2+ influx. Studies were conducted in cesium-loaded, tetrodotoxin-treated brain slice neurons in which known contaminating currents were blocked. These results therefore provide the first clear evidence that apparent Ca2+-mediated inactivation of ICa is an important mechanism with which mammalian brain neurons limit Ca2+ influx.
|Number of pages||7|
|State||Published - Apr 28 1987|
Bibliographical noteFunding Information:
This research was supported in part by Grants AG 04542 and AG 04207 from the NIH. We appreciate the excellent technical assistance of D.S. Kerr and the valuable clerical assistance of D. Lefler.
- Ca current
- Ca spike
- Vertebrate central nervous system
ASJC Scopus subject areas
- Neuroscience (all)
- Molecular Biology
- Clinical Neurology
- Developmental Biology