Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons

Thomas A. Pitler; Philip W. Landfield

doi:10.1016/S0006-8993(87)80037-9

Probable Ca²⁺-mediated inactivation of Ca²⁺ currents in mammalian brain neurons

Thomas A. Pitler, Philip W. Landfield

Pharmacology and Nutritional Sciences

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

In rat hippocampal neurons, current- and single-electrode voltage-clamp analyses revealed a pronounced inactivation of probable Ca²⁺ currents (I_Ca), which was dependent on the amount of Ca²⁺ influx. Studies were conducted in cesium-loaded, tetrodotoxin-treated brain slice neurons in which known contaminating currents were blocked. These results therefore provide the first clear evidence that apparent Ca²⁺-mediated inactivation of I_Ca is an important mechanism with which mammalian brain neurons limit Ca²⁺ influx.

Original language	English
Pages (from-to)	147-153
Number of pages	7
Journal	Brain Research
Volume	410
Issue number	1
DOIs	https://doi.org/10.1016/S0006-8993(87)80037-9
State	Published - Apr 28 1987

Bibliographical note

Funding Information:
This research was supported in part by Grants AG 04542 and AG 04207 from the NIH. We appreciate the excellent technical assistance of D.S. Kerr and the valuable clerical assistance of D. Lefler.

Keywords

Ca current
Ca spike
Conductance
Hippocampus
Inactivation
Vertebrate central nervous system
Voltage-clamp

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/S0006-8993(87)80037-9

Cite this

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title = "Probable Ca2+-mediated inactivation of Ca2+ currents in mammalian brain neurons",

abstract = "In rat hippocampal neurons, current- and single-electrode voltage-clamp analyses revealed a pronounced inactivation of probable Ca2+ currents (ICa), which was dependent on the amount of Ca2+ influx. Studies were conducted in cesium-loaded, tetrodotoxin-treated brain slice neurons in which known contaminating currents were blocked. These results therefore provide the first clear evidence that apparent Ca2+-mediated inactivation of ICa is an important mechanism with which mammalian brain neurons limit Ca2+ influx.",

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author = "Pitler, {Thomas A.} and Landfield, {Philip W.}",

note = "Funding Information: This research was supported in part by Grants AG 04542 and AG 04207 from the NIH. We appreciate the excellent technical assistance of D.S. Kerr and the valuable clerical assistance of D. Lefler.",

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AU - Landfield, Philip W.

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N2 - In rat hippocampal neurons, current- and single-electrode voltage-clamp analyses revealed a pronounced inactivation of probable Ca2+ currents (ICa), which was dependent on the amount of Ca2+ influx. Studies were conducted in cesium-loaded, tetrodotoxin-treated brain slice neurons in which known contaminating currents were blocked. These results therefore provide the first clear evidence that apparent Ca2+-mediated inactivation of ICa is an important mechanism with which mammalian brain neurons limit Ca2+ influx.

AB - In rat hippocampal neurons, current- and single-electrode voltage-clamp analyses revealed a pronounced inactivation of probable Ca2+ currents (ICa), which was dependent on the amount of Ca2+ influx. Studies were conducted in cesium-loaded, tetrodotoxin-treated brain slice neurons in which known contaminating currents were blocked. These results therefore provide the first clear evidence that apparent Ca2+-mediated inactivation of ICa is an important mechanism with which mammalian brain neurons limit Ca2+ influx.

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KW - Conductance

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KW - Inactivation

KW - Vertebrate central nervous system

KW - Voltage-clamp

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