TY - JOUR
T1 - Probing implicit learning in obsessive-compulsive disorder
T2 - Moderating role of medication on the weather prediction task
AU - Kelmendi, Benjamin
AU - Adams, Thomas
AU - Jakubovski, Ewgeni
AU - Hawkins, Keith A.
AU - Coric, Vladimir
AU - Pittenger, Christopher
N1 - Publisher Copyright:
© 2016 Elsevier Inc.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Deficits in implicit learning, a process by which knowledge is acquired accretively through practice independent of conscious awareness, have been implicated in Obsessive-compulsive disorder (OCD). The weather-prediction task (WPT) was used to assess implicit learning in 26 unmedicated patients with OCD and 23 healthy controls. An additional analysis compared these two groups with 25 medicated patients with OCD. In the comparison of unmedicated patients with healthy controls there was a subtle but statistically significant group-by-block interaction. Patients with OCD showed slower improvement in performance during the middle phase of learning. In a three-group comparison, there was no main effect of group; in post-hoc tests, medicated patients with OCD differed from unmedicated patients and were not different from healthy controls. Unmedicated patients with OCD have a subtle deficit in implicit learning in the WPT. This may be mitigated by pharmacotherapy, although prospective studies would be required to confirm this conclusion.
AB - Deficits in implicit learning, a process by which knowledge is acquired accretively through practice independent of conscious awareness, have been implicated in Obsessive-compulsive disorder (OCD). The weather-prediction task (WPT) was used to assess implicit learning in 26 unmedicated patients with OCD and 23 healthy controls. An additional analysis compared these two groups with 25 medicated patients with OCD. In the comparison of unmedicated patients with healthy controls there was a subtle but statistically significant group-by-block interaction. Patients with OCD showed slower improvement in performance during the middle phase of learning. In a three-group comparison, there was no main effect of group; in post-hoc tests, medicated patients with OCD differed from unmedicated patients and were not different from healthy controls. Unmedicated patients with OCD have a subtle deficit in implicit learning in the WPT. This may be mitigated by pharmacotherapy, although prospective studies would be required to confirm this conclusion.
KW - Implicit learning
KW - Obsessive-compulsive disorder
KW - Pharmacotherapy
KW - Weather prediction task
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U2 - 10.1016/j.jocrd.2016.03.003
DO - 10.1016/j.jocrd.2016.03.003
M3 - Article
AN - SCOPUS:84962799360
SN - 2211-3649
VL - 9
SP - 90
EP - 95
JO - Journal of Obsessive-Compulsive and Related Disorders
JF - Journal of Obsessive-Compulsive and Related Disorders
ER -