Probing implicit learning in obsessive-compulsive disorder: Moderating role of medication on the weather prediction task

Benjamin Kelmendi; Thomas Adams; Ewgeni Jakubovski; Keith A. Hawkins; Vladimir Coric; Christopher Pittenger

doi:10.1016/j.jocrd.2016.03.003

Probing implicit learning in obsessive-compulsive disorder: Moderating role of medication on the weather prediction task

Benjamin Kelmendi, Thomas Adams, Ewgeni Jakubovski, Keith A. Hawkins, Vladimir Coric, Christopher Pittenger

Psychology

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Deficits in implicit learning, a process by which knowledge is acquired accretively through practice independent of conscious awareness, have been implicated in Obsessive-compulsive disorder (OCD). The weather-prediction task (WPT) was used to assess implicit learning in 26 unmedicated patients with OCD and 23 healthy controls. An additional analysis compared these two groups with 25 medicated patients with OCD. In the comparison of unmedicated patients with healthy controls there was a subtle but statistically significant group-by-block interaction. Patients with OCD showed slower improvement in performance during the middle phase of learning. In a three-group comparison, there was no main effect of group; in post-hoc tests, medicated patients with OCD differed from unmedicated patients and were not different from healthy controls. Unmedicated patients with OCD have a subtle deficit in implicit learning in the WPT. This may be mitigated by pharmacotherapy, although prospective studies would be required to confirm this conclusion.

Original language	English
Pages (from-to)	90-95
Number of pages	6
Journal	Journal of Obsessive-Compulsive and Related Disorders
Volume	9
DOIs	https://doi.org/10.1016/j.jocrd.2016.03.003
State	Published - Apr 1 2016

Bibliographical note

Funding Information:
The authors gratefully acknowledge the support of Michael Bloch, MD, Suzanne Wasylink, RN-C, Eileen Billingslea, MA, and Lisa Sander, MD, in the recruitment and characterization of the participants described in this study. This work was supported by NIH grant K08MH081190 and by the State of Connecticut through its support of the Ribicoff Research Facilities at the Connecticut Mental Health Center. We thank Barbara Knowlton for providing the Weather Prediction Task.

Publisher Copyright:
© 2016 Elsevier Inc.

Keywords

Implicit learning
Obsessive-compulsive disorder
Pharmacotherapy
Weather prediction task

ASJC Scopus subject areas

Clinical Psychology
Psychiatry and Mental health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jocrd.2016.03.003

Cite this

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title = "Probing implicit learning in obsessive-compulsive disorder: Moderating role of medication on the weather prediction task",

abstract = "Deficits in implicit learning, a process by which knowledge is acquired accretively through practice independent of conscious awareness, have been implicated in Obsessive-compulsive disorder (OCD). The weather-prediction task (WPT) was used to assess implicit learning in 26 unmedicated patients with OCD and 23 healthy controls. An additional analysis compared these two groups with 25 medicated patients with OCD. In the comparison of unmedicated patients with healthy controls there was a subtle but statistically significant group-by-block interaction. Patients with OCD showed slower improvement in performance during the middle phase of learning. In a three-group comparison, there was no main effect of group; in post-hoc tests, medicated patients with OCD differed from unmedicated patients and were not different from healthy controls. Unmedicated patients with OCD have a subtle deficit in implicit learning in the WPT. This may be mitigated by pharmacotherapy, although prospective studies would be required to confirm this conclusion.",

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author = "Benjamin Kelmendi and Thomas Adams and Ewgeni Jakubovski and Hawkins, {Keith A.} and Vladimir Coric and Christopher Pittenger",

note = "Funding Information: The authors gratefully acknowledge the support of Michael Bloch, MD, Suzanne Wasylink, RN-C, Eileen Billingslea, MA, and Lisa Sander, MD, in the recruitment and characterization of the participants described in this study. This work was supported by NIH grant K08MH081190 and by the State of Connecticut through its support of the Ribicoff Research Facilities at the Connecticut Mental Health Center. We thank Barbara Knowlton for providing the Weather Prediction Task. Publisher Copyright: {\textcopyright} 2016 Elsevier Inc.",

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AU - Hawkins, Keith A.

AU - Coric, Vladimir

AU - Pittenger, Christopher

N1 - Funding Information: The authors gratefully acknowledge the support of Michael Bloch, MD, Suzanne Wasylink, RN-C, Eileen Billingslea, MA, and Lisa Sander, MD, in the recruitment and characterization of the participants described in this study. This work was supported by NIH grant K08MH081190 and by the State of Connecticut through its support of the Ribicoff Research Facilities at the Connecticut Mental Health Center. We thank Barbara Knowlton for providing the Weather Prediction Task. Publisher Copyright: © 2016 Elsevier Inc.

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N2 - Deficits in implicit learning, a process by which knowledge is acquired accretively through practice independent of conscious awareness, have been implicated in Obsessive-compulsive disorder (OCD). The weather-prediction task (WPT) was used to assess implicit learning in 26 unmedicated patients with OCD and 23 healthy controls. An additional analysis compared these two groups with 25 medicated patients with OCD. In the comparison of unmedicated patients with healthy controls there was a subtle but statistically significant group-by-block interaction. Patients with OCD showed slower improvement in performance during the middle phase of learning. In a three-group comparison, there was no main effect of group; in post-hoc tests, medicated patients with OCD differed from unmedicated patients and were not different from healthy controls. Unmedicated patients with OCD have a subtle deficit in implicit learning in the WPT. This may be mitigated by pharmacotherapy, although prospective studies would be required to confirm this conclusion.

AB - Deficits in implicit learning, a process by which knowledge is acquired accretively through practice independent of conscious awareness, have been implicated in Obsessive-compulsive disorder (OCD). The weather-prediction task (WPT) was used to assess implicit learning in 26 unmedicated patients with OCD and 23 healthy controls. An additional analysis compared these two groups with 25 medicated patients with OCD. In the comparison of unmedicated patients with healthy controls there was a subtle but statistically significant group-by-block interaction. Patients with OCD showed slower improvement in performance during the middle phase of learning. In a three-group comparison, there was no main effect of group; in post-hoc tests, medicated patients with OCD differed from unmedicated patients and were not different from healthy controls. Unmedicated patients with OCD have a subtle deficit in implicit learning in the WPT. This may be mitigated by pharmacotherapy, although prospective studies would be required to confirm this conclusion.

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Probing implicit learning in obsessive-compulsive disorder: Moderating role of medication on the weather prediction task

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

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