Progesterone receptor membrane component 1/ Sigma-2 receptor associates with MAP1LC3B and promotes autophagy

Shakeel U.R. Mir; Steven R. Schwarze; Ling Jin; Jinling Zhang; Woodrow Friend; Sumitra Miriyala; Daret St Clair; Rolf J. Craven

doi:10.4161/auto.25889

Progesterone receptor membrane component 1/ Sigma-2 receptor associates with MAP1LC3B and promotes autophagy

Shakeel U.R. Mir, Steven R. Schwarze, Ling Jin, Jinling Zhang, Woodrow Friend, Sumitra Miriyala, Daret St Clair, Rolf J. Craven

Research output: Contribution to journal › Article › peer-review

67 Scopus citations

Abstract

AMPK, AMP-dependent protein kinase; BCL2, B-cell lymphoma 2; BECN1, Beclin 1, autophagy related; CCNA1, cyclin A1; CTSD, cathepsin D; EGFR, epidermal growth factor receptor; FACS, fluorescence-activated cell sorting; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GFP, green fluorescent protein; JNK, c-JUN N-terminal kinase; LAMP1, lysosomal-associated membrane protein 1; MAP1LC3, microtubule-associated protein 1 light chain 3; MMP9, matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase); MTOR, mechanistic target of rapamycin; PGRMC1, progesterone-associated membrane component 1; RPS6KB/p70S6K, ribosomal protein S6 kinase, 70 kDa, polypeptide/ p70 S6 kinase; RNAi, RNA interference; SQSTM1, sequestosome 1; TSC, tuberous sclerosis complex; TUBA, tubulin A; UVRAG, UV radiation-resistance associated; VPS16, vacuolar protein sorting 16 homolog (S. cerevisiae).

Original language	English
Pages (from-to)	1566-1578
Number of pages	13
Journal	Autophagy
Volume	9
Issue number	10
DOIs	https://doi.org/10.4161/auto.25889
State	Published - Oct 2013

Bibliographical note

Funding Information:
The authors thank Mary Gail Engle and Jim Begley for their expertise with confocal and electron microscopy and Matthew Thacker for expert technical assistance. This work supported by grants from the Kentucky Lung Cancer Research Program, the Bonnie Addario Lung Cancer Foundation and the Kentucky Science and Education Fund (KSEF-2064-RDE-013).

Keywords

Autophagy
Metabolism
TOR
Therapeutics
Ubiquitin

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.4161/auto.25889

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title = "Progesterone receptor membrane component 1/ Sigma-2 receptor associates with MAP1LC3B and promotes autophagy",

abstract = "AMPK, AMP-dependent protein kinase; BCL2, B-cell lymphoma 2; BECN1, Beclin 1, autophagy related; CCNA1, cyclin A1; CTSD, cathepsin D; EGFR, epidermal growth factor receptor; FACS, fluorescence-activated cell sorting; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GFP, green fluorescent protein; JNK, c-JUN N-terminal kinase; LAMP1, lysosomal-associated membrane protein 1; MAP1LC3, microtubule-associated protein 1 light chain 3; MMP9, matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase); MTOR, mechanistic target of rapamycin; PGRMC1, progesterone-associated membrane component 1; RPS6KB/p70S6K, ribosomal protein S6 kinase, 70 kDa, polypeptide/ p70 S6 kinase; RNAi, RNA interference; SQSTM1, sequestosome 1; TSC, tuberous sclerosis complex; TUBA, tubulin A; UVRAG, UV radiation-resistance associated; VPS16, vacuolar protein sorting 16 homolog (S. cerevisiae).",

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author = "Mir, {Shakeel U.R.} and Schwarze, {Steven R.} and Ling Jin and Jinling Zhang and Woodrow Friend and Sumitra Miriyala and Clair, {Daret St} and Craven, {Rolf J.}",

note = "Funding Information: The authors thank Mary Gail Engle and Jim Begley for their expertise with confocal and electron microscopy and Matthew Thacker for expert technical assistance. This work supported by grants from the Kentucky Lung Cancer Research Program, the Bonnie Addario Lung Cancer Foundation and the Kentucky Science and Education Fund (KSEF-2064-RDE-013).",

year = "2013",

month = oct,

doi = "10.4161/auto.25889",

language = "English",

volume = "9",

pages = "1566--1578",

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T1 - Progesterone receptor membrane component 1/ Sigma-2 receptor associates with MAP1LC3B and promotes autophagy

AU - Mir, Shakeel U.R.

AU - Schwarze, Steven R.

AU - Jin, Ling

AU - Zhang, Jinling

AU - Friend, Woodrow

AU - Miriyala, Sumitra

AU - Clair, Daret St

AU - Craven, Rolf J.

N1 - Funding Information: The authors thank Mary Gail Engle and Jim Begley for their expertise with confocal and electron microscopy and Matthew Thacker for expert technical assistance. This work supported by grants from the Kentucky Lung Cancer Research Program, the Bonnie Addario Lung Cancer Foundation and the Kentucky Science and Education Fund (KSEF-2064-RDE-013).

PY - 2013/10

Y1 - 2013/10

N2 - AMPK, AMP-dependent protein kinase; BCL2, B-cell lymphoma 2; BECN1, Beclin 1, autophagy related; CCNA1, cyclin A1; CTSD, cathepsin D; EGFR, epidermal growth factor receptor; FACS, fluorescence-activated cell sorting; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GFP, green fluorescent protein; JNK, c-JUN N-terminal kinase; LAMP1, lysosomal-associated membrane protein 1; MAP1LC3, microtubule-associated protein 1 light chain 3; MMP9, matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase); MTOR, mechanistic target of rapamycin; PGRMC1, progesterone-associated membrane component 1; RPS6KB/p70S6K, ribosomal protein S6 kinase, 70 kDa, polypeptide/ p70 S6 kinase; RNAi, RNA interference; SQSTM1, sequestosome 1; TSC, tuberous sclerosis complex; TUBA, tubulin A; UVRAG, UV radiation-resistance associated; VPS16, vacuolar protein sorting 16 homolog (S. cerevisiae).

AB - AMPK, AMP-dependent protein kinase; BCL2, B-cell lymphoma 2; BECN1, Beclin 1, autophagy related; CCNA1, cyclin A1; CTSD, cathepsin D; EGFR, epidermal growth factor receptor; FACS, fluorescence-activated cell sorting; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GFP, green fluorescent protein; JNK, c-JUN N-terminal kinase; LAMP1, lysosomal-associated membrane protein 1; MAP1LC3, microtubule-associated protein 1 light chain 3; MMP9, matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase); MTOR, mechanistic target of rapamycin; PGRMC1, progesterone-associated membrane component 1; RPS6KB/p70S6K, ribosomal protein S6 kinase, 70 kDa, polypeptide/ p70 S6 kinase; RNAi, RNA interference; SQSTM1, sequestosome 1; TSC, tuberous sclerosis complex; TUBA, tubulin A; UVRAG, UV radiation-resistance associated; VPS16, vacuolar protein sorting 16 homolog (S. cerevisiae).

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KW - Metabolism

KW - TOR

KW - Therapeutics

KW - Ubiquitin

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Progesterone receptor membrane component 1/ Sigma-2 receptor associates with MAP1LC3B and promotes autophagy

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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