Progesterone receptor membrane component 1/ Sigma-2 receptor associates with MAP1LC3B and promotes autophagy

Shakeel U.R. Mir, Steven R. Schwarze, Ling Jin, Jinling Zhang, Woodrow Friend, Sumitra Miriyala, Daret St Clair, Rolf J. Craven

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


AMPK, AMP-dependent protein kinase; BCL2, B-cell lymphoma 2; BECN1, Beclin 1, autophagy related; CCNA1, cyclin A1; CTSD, cathepsin D; EGFR, epidermal growth factor receptor; FACS, fluorescence-activated cell sorting; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GFP, green fluorescent protein; JNK, c-JUN N-terminal kinase; LAMP1, lysosomal-associated membrane protein 1; MAP1LC3, microtubule-associated protein 1 light chain 3; MMP9, matrix metallopeptidase 9 (gelatinase B, 92 kDa gelatinase, 92 kDa type IV collagenase); MTOR, mechanistic target of rapamycin; PGRMC1, progesterone-associated membrane component 1; RPS6KB/p70S6K, ribosomal protein S6 kinase, 70 kDa, polypeptide/ p70 S6 kinase; RNAi, RNA interference; SQSTM1, sequestosome 1; TSC, tuberous sclerosis complex; TUBA, tubulin A; UVRAG, UV radiation-resistance associated; VPS16, vacuolar protein sorting 16 homolog (S. cerevisiae).

Original languageEnglish
Pages (from-to)1566-1578
Number of pages13
Issue number10
StatePublished - Oct 2013

Bibliographical note

Funding Information:
The authors thank Mary Gail Engle and Jim Begley for their expertise with confocal and electron microscopy and Matthew Thacker for expert technical assistance. This work supported by grants from the Kentucky Lung Cancer Research Program, the Bonnie Addario Lung Cancer Foundation and the Kentucky Science and Education Fund (KSEF-2064-RDE-013).


  • Autophagy
  • Metabolism
  • TOR
  • Therapeutics
  • Ubiquitin

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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