Programmed DNA Elimination in Vertebrates

Jeramiah J. Smith, Vladimir A. Timoshevskiy, Cody Saraceno

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


Over the last few decades, an increasing number of vertebrate taxa have been identified that undergo programmed genome rearrangement, or programmed DNA loss, during development. In these organisms, the genome of germ cells is often reproducibly different from the genome of all other cells within the body. Although we clearly have not identified all vertebrate taxa that undergo programmed genome loss, the list of species known to undergo loss now represents sim 10% of vertebrate species, including several basally diverging lineages. Recent studies have shed new light on the targets and mechanisms of DNA loss and their association with canonical modes of DNA silencing. Ultimately, expansion of these studies into a larger collection of taxa will aid in reconstructing patterns of shared/independent ancestry of programmed DNA loss in the vertebrate lineage, as well as more recent evolutionary events that have shaped the structure and content of eliminated DNA.

Original languageEnglish
Pages (from-to)173-201
Number of pages29
JournalAnnual Review of Animal Biosciences
StatePublished - Feb 15 2021

Bibliographical note

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  • evolution
  • genome
  • programmed DNA loss
  • programmed genome rearrangement
  • vertebrate

ASJC Scopus subject areas

  • Biotechnology
  • Animal Science and Zoology
  • Genetics
  • Veterinary (all)


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