Prolonged Allograft Survival in a Patient with Chronic Immunosuppression: A Case Report and Systematic Review

Krishna S. Vyas, Chase Burns, Dylan T. Ryan, Lesley Wong

Research output: Contribution to journalReview articlepeer-review

4 Scopus citations

Abstract

A 41-year-old man with past medical history of kidney-liver transplantation requiring chronic immunosuppression presented 2 years posttransplant with a necrotizing soft tissue infection of his right thigh. Serial debridement to remove necrotic tissue was performed, and a Matrix HD Allograft Fenestrated (RTI Surgical, Alachua, FL) was applied. At 5-months post grafting, the patient demonstrated fully vascularized and intact skin. Under normal circumstances, a cadaveric allograft sloughs over several weeks and is not usually considered a permanent solution for wound closure. A systematic review of transplant patients on chronic immunosuppression with skin allografts demonstrates the potential for the indefinite survival of an allograft. Necrotizing soft tissue infections can definitively be treated using serial debridement and allograft transplantation in the chronically immunosuppressed.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalWounds
Volume29
Issue number6
StatePublished - Jun 2017

Keywords

  • immunosuppression
  • necrotizing soft tissue wound management
  • posttransplant wound management
  • prolonged allograft survival

ASJC Scopus subject areas

  • Surgery
  • Medical–Surgical

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